{"id":6,"date":"2012-03-21T17:10:18","date_gmt":"2012-03-21T17:10:18","guid":{"rendered":"http:\/\/pages.charlotte.edu\/valery-grdzelishvili\/?page_id=6"},"modified":"2026-04-03T18:47:32","modified_gmt":"2026-04-03T18:47:32","slug":"home","status":"publish","type":"page","link":"http:\/\/pages.charlotte.edu\/valery-grdzelishvili\/","title":{"rendered":"GRDZELISHVILI LAB Molecular Virology and Oncolytic Virotherapy for Pancreatic Cancer"},"content":{"rendered":"\n

Valery Z. Grdzelishvili, Ph.D.<\/strong><\/h2>\n\n\n\n

Professor, Molecular Virology and Cancer Therapy<\/strong><\/em><\/h3>\n\n\n
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Dr. Grdzelishvili\u2019s laboratory focuses on the molecular biology of nonsegmented negative-strand (NNS) RNA viruses (order Mononegavirales<\/em>). This group includes several significant human and animal pathogens, such as rabies, measles, mumps, Ebola, Marburg, Nipah, and Hendra viruses. The laboratory is particularly interested engineering NNS RNA viruses, primarily vesicular stomatitis virus (VSV), as replication-competent oncolytic agents for cancer therapy. A major area of research involves identifying viral and cellular factors that influence the susceptibility or resistance of pancreatic cancer cells to VSV and other oncolytic viruses, as well as developing innovative strategies to overcome resistance to oncolytic virotherapy in pancreatic cancer.<\/strong><\/h5>\n\n\n\n

Publications at PubMed<\/a><\/strong> \/ Dr. Grdzelishvili’s Google Scholar Profile<\/a><\/strong> \/ Grdzelishvili Lab Twitter<\/strong><\/a><\/p>\n\n\n\n

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Keywords: <\/strong>molecular virology, cancer biology, anticancer therapy based on replication-competent viruses (“oncolytic virotherapy”), virus-host interactions in normal and cancer cells, host factors of virus replication in normal and cancer cells, innate immunity in normal and cancer cells, virus-based gene therapy, vaccine vectors, negative-strand RNA viruses (order Mononegavirales)<\/em><\/p>\n\n\n\n

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Left to Right (click to expand): <\/em>Valery Grdzelishvili, Timo Taffe, Matthew Widrick, Cassandra (Cassie) Catacalos, Nathaniel Foret, Emanuel Helleryd, <\/strong>David Janumyan, <\/strong>, Kyra Price<\/strong>, Jacob Hawkins, Charlotte Johnstone<\/strong><\/p>\n\n\n\n

Second Row: <\/em>Sophie the Sheltie<\/strong><\/p>\n\n\n\n

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Valery Z. Grdzelishvili, Ph.D. \/ Short Bio<\/strong><\/h3>\n
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Academic Degrees<\/strong><\/p>\n