{"id":5,"date":"2012-10-25T22:04:15","date_gmt":"2012-10-25T22:04:15","guid":{"rendered":"http:\/\/pages.charlotte.edu\/template-faculty01\/?page_id=5"},"modified":"2015-08-24T01:23:28","modified_gmt":"2015-08-24T01:23:28","slug":"home","status":"publish","type":"page","link":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/","title":{"rendered":"Home"},"content":{"rendered":"<p><a href=\"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-content\/uploads\/sites\/134\/2012\/10\/yuri.nesmelov.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-12\" title=\"yuri.nesmelov\" alt=\"\" src=\"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-content\/uploads\/sites\/134\/2012\/10\/yuri.nesmelov-224x300.jpg\" width=\"224\" height=\"300\" srcset=\"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-content\/uploads\/sites\/134\/2012\/10\/yuri.nesmelov-224x300.jpg 224w, http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-content\/uploads\/sites\/134\/2012\/10\/yuri.nesmelov.jpg 248w\" sizes=\"auto, (max-width: 224px) 100vw, 224px\" \/><\/a><\/p>\n<p><span style=\"text-decoration: underline\"><strong>Research Interests:<\/strong><\/span><\/p>\n<p>My research interests are focused on biological molecular motors. I study myosin II, the protein responsible for force generation in muscle, cell locomotion and intracellular trafficking. I combine protein\u00a0mutagenesis,\u00a0site directed labeling,\u00a0multifrequency\u00a0Electron Paramagnetic Resonance (EPR) and transient time-resolved fluorescence resonance energy transfer (TR<sup>2<\/sup>FRET) to explore myosin functional dynamics on molecular and submolecular\u00a0level. The ultimate goal of these studies is to determine the mechanism of force generation in myosin.<\/p>\n<p>I am also interested in manipulating of microwave field distribution in EPR cavity to maximize sensitivity of EPR measurement for aqueous samples, through the sample geometry optimization and usage of ferroelectric\/dielectric cavity inserts.<\/p>\n<p>                                             Please visit NesmelovLab web page for more details<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests: My research interests are focused on biological molecular motors. I study myosin II, the protein responsible for force generation in muscle, cell locomotion and intracellular trafficking. I combine protein\u00a0mutagenesis,\u00a0site directed labeling,\u00a0multifrequency\u00a0Electron Paramagnetic Resonance (EPR) and transient time-resolved fluorescence resonance energy transfer (TR2FRET) to explore myosin functional dynamics on molecular and submolecular\u00a0level. The ultimate [&hellip;]<\/p>\n","protected":false},"author":698,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P2R2bT-5","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/users\/698"}],"replies":[{"embeddable":true,"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":10,"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":26,"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/pages\/5\/revisions\/26"}],"wp:attachment":[{"href":"http:\/\/pages.charlotte.edu\/yuri-nesmelov\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}