We are more than what we publish but here is an idea of the work we have been involved in!
Dasgupta Postdoc Publications (2019-2025)
Dasgupta A,* Schmitt RE, Kono T, Lee CC, Zoberi MI, Epstein SA, Schneider JZ, Hernandez A, Grandgenett PM, Caffrey TC, DiMaio DJ, Hollingsworth MA, Doles JD*. Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting. J Exp Med. 2025 Sep 1;222(9). doi: 10.1084/jem.20242239. Epub 2025 Jul 2. PubMed PMID: 40600951; PubMed Central PMCID: PMC12237250. *co-corresponding authors
Epstein SA, Dasgupta A, Doles JD. Promising preclinical approaches to combating cancer-associated cachexia/tissue wasting. Curr Opin Support Palliat Care. 2025 Sep 1;19(3):175-179. doi: 10.1097/SPC.0000000000000763. Epub 2025 Jul 29. Review. PubMed PMID: 40492746.
Doles MD, Dasgupta A, Ribera A, Doles JD. Forward Mentoring: A Reverse Mentoring-Inspired Initiative to Enhance Cultural Humility and Promote Academic Leadership Capacity. Med Sci Educ. 2025 Aug;35(4):2175-2185. doi: 10.1007/s40670-025-02395-8. eCollection 2025 Aug. PubMed PMID: 41112895; PubMed Central PMCID: PMC12532522.
Epstein SA, Doles JD, Dasgupta A. KLF10: a point of convergence in cancer cachexia. Curr Opin Support Palliat Care. 2024 Sep 1;18(3):120-125. doi: 10.1097/SPC.0000000000000711. Epub 2024 Jul 15. Review. PubMed PMID: 39007915; PubMed Central PMCID: PMC11293965.
Dasgupta A*# ,Gibbard DF#, Schmitt RE, Arneson-Wissink PC, Ducharme AM, Bruinsma ES, Hawse JR, Jatoi A, Doles JD*. A TGF-β/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2215095120. doi: 10.1073/pnas.2215095120. Epub 2023 Aug 16. PubMed PMID: 37585460; PubMed Central PMCID: PMC10462925. *co-corresponding authors, #co-first authors
Neyroud D, Laitano O, Dasgupta A, Lopez C, Schmitt RE, Schneider JZ, Hammers DW, Sweeney HL, Walter GA, Doles J, Judge SM, Judge AR. Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth. Commun Biol. 2023 May 13;6(1):519. doi: 10.1038/s42003-023-04902-2. PubMed PMID: 37179425; PubMed Central PMCID: PMC10183033.
Schmitt RE, Dasgupta A, Arneson-Wissink PC, Datta S, Ducharme AM, Doles JD. Muscle stem cells contribute to long-term tissue repletion following surgical sepsis. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1424-1440. doi: 10.1002/jcsm.13214. Epub 2023 Mar 8. PubMed PMID: 36883680; PubMed Central PMCID: PMC10235871.
Nicolau S, Dasgupta A, Dasari S, Charlesworth MC, Johnson KL, Pandey A, Doles JD, Milone M. Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies. Acta Neuropathol Commun. 2023 Jan 26;11(1):20. doi: 10.1186/s40478-023-01518-9. PubMed PMID: 36703211; PubMed Central PMCID: PMC9878979.
Dasgupta A, Arneson-Wissink PC, Schmitt RE, Cho DS, Ducharme AM, Hogenson TL, Krueger EW, Bamlet WR, Zhang L, Razidlo GL, Fernandez-Zapico ME, Doles JD. Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer. JCI Insight. 2022 Jan 25;7(2). doi: 10.1172/jci.insight.153842. PubMed PMID: 34874916; PubMed Central PMCID: PMC8855816.
Dasgupta PhD Publications (2014-2019)
Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 Jul 6;217(7). doi: 10.1084/jem.20190745. PubMed PMID: 32441762; PubMed Central PMCID: PMC7336299.
Mulder SE, Dasgupta A, King RJ, Abrego J, Attri KS, Murthy D, Shukla SK, Singh PK. JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia. Cancer Lett. 2020 Oct 28;491:70-77. doi: 10.1016/j.canlet.2020.07.025. Epub 2020 Jul 28. PubMed PMID: 32735910; PubMed Central PMCID: PMC7541723.
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 Sep 11;32(3):392. doi: 10.1016/j.ccell.2017.08.008. PubMed PMID: 28898700.
King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 Feb;41(7):971-982. doi: 10.1038/s41388-021-02132-6. Epub 2022 Jan 10. PubMed PMID: 35001076; PubMed Central PMCID: PMC8840971
Mulder SE, Dasgupta A, King RJ, Abrego J, Attri KS, Murthy D, Shukla SK, Singh PK. JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia. Cancer Lett. 2020 Oct 28;491:70-77. doi: 10.1016/j.canlet.2020.07.025. Epub 2020 Jul 28. PubMed PMID: 32735910; PubMed Central PMCID: PMC7541723.
Dasgupta A, Shukla SK, Gunda V, King RJ, Singh PK. Evaluating the Metabolic Alterations in Pancreatic Cancer. Methods Mol Biol. 2019;1882:221-228. doi: 10.1007/978-1-4939-8879-2_20. PubMed PMID: 30378058.
Gunda V, Souchek J, Abrego J, Shukla SK, Goode GD, Vernucci E, Dasgupta A, Chaika NV, King RJ, Li S, Wang S, Yu F, Bessho T, Lin C, Singh PK. MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer. Clin Cancer Res. 2017 Oct 1;23(19):5881-5891. doi: 10.1158/1078-0432.CCR-17-1151. Epub 2017 Jul 18. PubMed PMID: 28720669; PubMed Central PMCID: PMC5626603.