{"id":34,"date":"2025-07-19T00:46:46","date_gmt":"2025-07-19T00:46:46","guid":{"rendered":"https:\/\/pages.charlotte.edu\/adasgup2\/?page_id=34"},"modified":"2026-01-30T15:16:41","modified_gmt":"2026-01-30T15:16:41","slug":"research","status":"publish","type":"page","link":"https:\/\/pages.charlotte.edu\/adasgup2\/","title":{"rendered":"What We’re Up To!"},"content":{"rendered":"
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Cancer cachexia is a multifactorial syndrome charaterized by irreversible weight loss. This weight loss entails both muscle and adipose tissue loss.

Cachectic patients have a poor response to chemotherapy or sometimes don’t qualify for the needed dose of chemotherapy. Cachectic cancer patients have a poor survival prognosis as compared to non-cachectic cancer patients.

The Dasgupta Lab is interested in understanding this syndrome further in order to develop novel therapeutic avenues to improve patient outcomes.<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

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Perp as a dual target in pancreatic cancer cachexia<\/strong><\/p>\n\n\n\n

We discovered the protein Perp to be overexpressed in pancreatic tumor and wasting muscle. A main aim of the lab is to investigate Perp-induced molecular mechanisms. <\/p>\n\n\n\n

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Read more about it in this paper!<\/a><\/p>\n<\/div>\n\n\n\n

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Novel Mechanisms in Cancer-associated cachexia<\/strong><\/p>\n\n\n\n

One of the main goals of the lab is to investigate novel targets in cancer-associated muscle wasting. We utilize in vitro<\/em> and in vivo<\/em> models of cachexia to attain this goal.<\/p>\n\n\n

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Read more about it in this paper!<\/a><\/p>\n<\/div>\n\n\n\n

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Investigating tumor-host crosstalk in cancer cachexia<\/strong><\/p>\n\n\n\n

We and others have reported decreased tumor-proliferation upon inhibiting muscle wasting in murine cancer models. The Dasgupta lab aims to investigate the underlying mechanisms of tumor-host crosstalk.<\/p>\n\n\n

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Read more about it in this paper!<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

Collaborative Projects :<\/strong><\/p>\n\n\n\n

Dasgupta lab has various collaborative projects with other labs! Keep a look out for updates about them in this space!<\/p>\n","protected":false},"excerpt":{"rendered":"

Perp as a dual target in pancreatic cancer cachexia We discovered the protein Perp to be overexpressed in pancreatic tumor and wasting muscle. A main aim of the lab is to investigate Perp-induced molecular mechanisms. Read more about it in this paper! Novel Mechanisms in Cancer-associated cachexia One of the main goals of the lab … Read more<\/a><\/p>\n","protected":false},"author":5092,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-34","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/users\/5092"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/comments?post=34"}],"version-history":[{"count":30,"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":305,"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/pages\/34\/revisions\/305"}],"wp:attachment":[{"href":"https:\/\/pages.charlotte.edu\/adasgup2\/wp-json\/wp\/v2\/media?parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}