{"id":5,"date":"2012-10-25T22:04:15","date_gmt":"2012-10-25T22:04:15","guid":{"rendered":"http:\/\/pages.charlotte.edu\/template-faculty01\/?page_id=5"},"modified":"2020-09-13T22:13:46","modified_gmt":"2020-09-14T02:13:46","slug":"home","status":"publish","type":"page","link":"https:\/\/pages.charlotte.edu\/andrew-truman\/","title":{"rendered":"Home"},"content":{"rendered":"\n<p>The Truman Lab has moved sites! Please see:<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"http:\/\/trumanlab.org\">Trumanlab.org<\/a><\/div>\n<\/div>\n\n\n\n<p>For undergraduate, graduate or postdoctoral research opportunities, please see here:<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/www.trumanlab.org\/open-positions\">Research Opportunities<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"253\" src=\"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-content\/uploads\/sites\/764\/2018\/10\/Truman-website-schematic3-300x253.jpg\" alt=\"\" class=\"wp-image-380\" srcset=\"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-content\/uploads\/sites\/764\/2018\/10\/Truman-website-schematic3-300x253.jpg 300w, https:\/\/pages.charlotte.edu\/andrew-truman\/wp-content\/uploads\/sites\/764\/2018\/10\/Truman-website-schematic3-768x647.jpg 768w, https:\/\/pages.charlotte.edu\/andrew-truman\/wp-content\/uploads\/sites\/764\/2018\/10\/Truman-website-schematic3-1024x863.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<p>Hsp70 and Hsp90 are well-conserved molecular chaperones that bind and fold a a large proportion of proteins in the cell. Many cancer proteins are <strong>inherently unstable<\/strong> and need chaperones to maintain activity. We are interested in the basic question\u00a0of the <strong>role of molecular chaperones in breast and prostate cancer<\/strong>.\u00a0 We are focused in novel ways to manipulate Hsp70 function by either inhibiting specific &#8220;helper&#8221; co-chaperone proteins such as Hsp40 or by modulating phosphorylation on Hsp70. By &#8220;fine-tuning&#8221; Hsp70 function, we hope to identify novel ways to destabilize cancer proteins. <\/p>\n\n\n\n<p>The Truman lab incorporates protein biochemistry, molecular biology, <span class=\"has-inline-color has-luminous-vivid-orange-color\"><strong>proteomics<\/strong><\/span>, systems biology,\u00a0bacterial and\u00a0yeast genetics and cell culture technologies. \u00a0<strong>Keywords:\u00a0<\/strong>protein-protein interactions,\u00a0protein folding,\u00a0<span class=\"has-inline-color has-luminous-vivid-orange-color\"><strong>CRISPR-CAS9<\/strong><\/span>, breast cancer,\u00a0signal transduction,\u00a0phosphorylation, Hsp70, Hsp90, cell cycle, DNA damage response, yeast genetics. \u00a0<\/p>\n\n\n\n<figure class=\"wp-block-embed-twitter aligncenter wp-block-embed is-type-rich is-provider-twitter\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-container\"><a class=\"twitter-timeline\" data-width=\"500\" data-height=\"750\" data-dnt=\"true\" href=\"https:\/\/twitter.com\/TrumanLab?ref_src=twsrc%5Etfw\">Tweets by TrumanLab<\/a><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/div>\n<\/div><\/figure>\n\n\n<div>\u00a0<\/div>\n<div><span style=\"color: #ffffff\">Hsp70<\/span><\/div>\n<div><span style=\"color: #ffffff\">Hsp70<\/span><\/div>\n<div><span style=\"color: #ffffff\">Hsp70<\/span><\/div>\n<div><span style=\"color: #ffffff\">Hsp70<\/span><\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div style=\"text-align: justify\">\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>","protected":false},"excerpt":{"rendered":"<p>The Truman Lab has moved sites! Please see: For undergraduate, graduate or postdoctoral research opportunities, please see here: Hsp70 and Hsp90 are well-conserved molecular chaperones that bind and fold a a large proportion of proteins in the cell. Many cancer proteins are inherently unstable and need chaperones to maintain activity. We are interested in the [&hellip;]<\/p>\n","protected":false},"author":1148,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/users\/1148"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":62,"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":488,"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/pages\/5\/revisions\/488"}],"wp:attachment":[{"href":"https:\/\/pages.charlotte.edu\/andrew-truman\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}