Date: February 21, 2020<\/p>\n\n\n\n
Time and location: 11:10am-12:10pm, Fretwell 305<\/p>\n\n\n\n
Speaker: Mingyao Li, Ph.D, Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania Perelman School of Medicine<\/p>\n\n\n\n
Title: Translation of single-cell genomics into human health: methods and applications<\/p>\n\n\n\n
Abstract: Recent technological breakthroughs have made it possible to measure gene expression at the single-cell level, thus allowing biologists and clinicians to better understand cellular heterogeneity and modify cell behavior through targeted molecular therapies. However, single-cell RNA sequencing protocols are complex. Even with the most sensitive platforms, the data are often noisy owing to a high frequency of dropout events, and the phenomenon of transcriptional bursting in which pulses of transcriptional activity are followed by inactive refractory periods. In this talk, I will present several statistical and machine learning methods that aim to tackle these challenges for a better understanding of cellular heterogeneity. I will illustrate our methods by showing results from ongoing collaborations on age-related macular degeneration and Alzheimer\u2019s disease. With the growing interest in utilizing single-cell RNA sequencing in biomedical research, our methods will aid biomedical researchers to answer medically related questions and make exciting discoveries.<\/p>\n","protected":false},"excerpt":{"rendered":"
Date: February 21, 2020 Time and location: 11:10am-12:10pm, Fretwell 305 Speaker: Mingyao Li, Ph.D, Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania Perelman School of Medicine Title: Translation of single-cell genomics into human health: methods and applications Abstract: Recent technological breakthroughs have made it possible to measure gene expression at the single-cell level, thus allowing biologists and clinicians […]<\/p>\n","protected":false},"author":1211,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-581","post","type-post","status-publish","format-standard","hentry","category-spring-2022"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p3kCtT-9n","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/posts\/581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/users\/1211"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/comments?post=581"}],"version-history":[{"count":2,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/posts\/581\/revisions"}],"predecessor-version":[{"id":583,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/posts\/581\/revisions\/583"}],"wp:attachment":[{"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/media?parent=581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/categories?post=581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pages.charlotte.edu\/colloquium\/wp-json\/wp\/v2\/tags?post=581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}