2023 Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren# (2023) Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
Cell Reports 2023 Sep 26;42(10):113136. doi: 10.1016/j.celrep.2023.113136.
2023 Steven Ingersoll, Kyle Brown, Brian Ma, and Xiaojun Ren# (2023) Quantifying the binding and target-search kinetics of transcriptional regulatory factors by live-cell single-molecule tracking.
Methods in Molecular Biology 2023; 2599:141-162. doi: 10.1007/978-1-0716-2847-8_11.
2022 Xiaowei Xu, Xu Hua, Kyle Brown, Xiaojun Ren, Zhiguo Zhang (2022) Mcm2 promotes stem cell differentiation via its ability to bind H3-H4.
Elife 2022 Nov 10:11: e80917. doi: 10.7554/eLife.80917.
2021 Kyle Brown, Samantha Kent, and Xiaojun Ren# (2021) Monitoring Binding and Target-search Dynamics of Epigenetic Regulatory Factors Using Live-Cell Single-Molecule Tracking.
STAR Protocols 2021 Nov 16;2(4):100959.
2021 Yi Zhang, Kyle Brown, Yucong Yu, Ziad Ibrahim, Mohamad Zandian, Hongwen Xuan, Steven Ingersoll, Thomas Lee, Christopher C Ebmeier, Jiuyang Liu, Daniel Panne, Xiaobing Shi, Xiaojun Ren, Tatiana G Kutateladze (2021) Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.
Nature Communications Jul 29; 12(1):4618.
2021 Kyle Brown, Haralambos Andrianakos, Steven Ingersoll, Xiaojun Ren# (2021) Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins.
Nucleic Acids Research Jul 9; 49(12):6621-6637
2020 Samantha Kent, Kyle Brown, Chou-hsun Yang, Njood Alsaihati, Christina Tian, Haobin Wang, Xiaojun Ren# (2020) Phase-separated Transcriptional Condensates Accelerate Target-search Process Revealed by Live-cell Single-molecule Imaging.
Cell Reports Oct 13; 33: 108248
2019 Yi Zhang, Bianca Bertulat, Adam H. Tencer, Xiaojun Ren, Gregory M. Wright, Joshua Black, M. Cristina Cardoso, Tatiana G. Kutateladze (2019) MORC3 Forms Nuclear Condensates through Phase Separation
iScience Jul 26; 17:182-189
2019 Roubina Tatavosian, Samantha Kent, Kyle Brown, Tingting Yao, Huy Nguyen Duc, Thao Ngoc Huynh, Chao Yu Zhen, Brian Ma, Haobin Wang, Xiaojun Ren# (2019) Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.
Journal of Biological Chemistry Feb 1; 294(5):1451-1463
- The year in the Journal of Biological Chemistry: 2019. The paper was selected to represent the exciting advance in gene regulation in 2019 by the JBC.
- Significant biochemistry papers from 100+ years of JBC. The paper was included in a collection of highlights (total 46 papers) published in the JBC during the last Century and beyond.
2018 Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang, Xiaojun Ren# (2018) Live-cell Single-Molecule Dynamics of PcG Proteins Imposed by the DIPG H3.3K27M Mutation.
Nature Communications May 25; 9(1):2080
2018 Roubina Tatavosian, Xiaojun Ren# (2018) Sm-ChIPi: Single-Molecule Chromatin Immunoprecipitation Imaging.
Methods in Molecular Biology 1689:113-126
2017 Huy Nguyen Duc, Xiaojun Ren# (2017) Labelling HaloTag Fusion Proteins with HaloTag Ligand in Living Cells.
Bio-protocol Sep 5; 7(17). Pii: e2526
2017 Thao Ngoc Huynh, Xiaojun Ren# (2017) Producing GST-Cbx7 Fusion Proteins from Escherichia coli.
Bio-protocol Jun 20; 7(12). Pii: e2333
2016 Chao Yu Zhen, Roubina Tatavosian, Thao Ngoc Huynh, Huy Nguyen Duc, Raibatak Das, Marko Kokotovic, Jonathan B Grimm, Luke D Lavis, Jun Lee, Frances J Mejia, Yang Li, Tingting Yao, Xiaojun Ren# (2016) Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets Polycomb Cbx7-PRC1 to chromatin.
eLIFE Oct 10; 5. Pii: e17667
2016 Yan Jiang, Xu Sun, Bin Li, Xiaojun Ren#, Hongwen Zhang, Rong Zhang (2016) Synthesis and characterization of monodisperse emulsion copolymer.
Chem. Res. Chin. Univ. 32: 134
2015 Roubina Tatavosian, Chao Yu Zhen, Huy Nguyen Duc, Maggie M. Balas, Aaron Johnson, Xiaojun Ren# (2015) Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-Molecule Chromatin Immunoprecipitation Imaging.
Journal of Biological Chemistry290(47):28038-54
- The Best of Year Article in Gene Regulation in 2015 by the JBC. The paper was honored to represent the best of year article in gene regulation in 2015 by the JBC.
2015 Roubina Tatavosian, Chao Yu Zhen, Xiaojun Ren# (2015) Single-Molecule Fluorescence Microscopy Methods in Chromatin Biology in Recent Progress in Surface and Colloids Chemistry with Biological Applications (Edited by Chengshan Wang and Roger M. Leblanc). ACS Symposium Series eBooks, Chapter 7, pp 129-136
2015 Colleen M. Bartmana, Jennifer Egelstona, Xiaojun Ren, Raibatak Das, and Christopher J. Phiel A (2015) simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine.
Experimental Cell Research 330(1):178-85
2014 Chao Yu Zhen, Huy Nguyen Duc, Marko Kokotovic, Christopher Phiel, Xiaojun Ren# (2014) Cbx2 stably associates with mitotic chromosomes via a PRC2 or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes.
Molecular Biology of the Cell25(23):3726-39
2014 Bo Cheng*, Xiaojun Ren*, Tom K Kerppola (2014) KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes.
Molecular and Cellular Biology 34(11):2075-91
*Contributed equally to this work
- One of the most read articles in May 2014
2011 Xiaojun Ren, Tom K Kerppola (2011) REST interacts with Cbx proteins and has opposite effects on polycomb repressive complex 1 at proximal versus distal RE1 elements.
Molecular and Cellular Biology 31 (10): 2100-2110
- Highlighted by MCB
2008 Xiaojun Ren, Claudius Vincenz, Tom K Kerppola (2008) Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation.
Molecular and Cellular Biology 28 (9): 2884-2895
- One of the most read articles in May 2008
2008 David Alves, Haitao Li, Rosalind Codrington, Angel Orte, Xiaojun Ren, David Klenerman, Shankar Balasubramanian (2008) Single-molecule analysis of human telomerase monomer.
Nature Chemical Biology 4 (5): 287-289
2006 Xiaojun Ren, Haitao Li, Richard W. Clarke, David A. Alves, Liming Ying, David Klenerman, Shankar Balasubramanian (2006) Analysis of human telomerase activity and function by two-color single molecule coincidence fluorescence spectroscopy.
Journal of the American Chemical Society128 (15): 4992-5000
2004 Haitao Li*, Xiaojun Ren*, Liming Ying, Shankar Balasubramanian, David Klenerman (2004) Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy.
PNAS 101(40): 14425-14430
*Contributed equally to this work
2004 Haitao Li, Liming Ying, Xiaojun Ren, Balasubramanian S, Klenerman D (2004) Fluorescence studies of single biomolecules.
Biochemical Society Transactions 32(5): 753-756
2004 Zeyuan Dong, Junqiu Liu, Shizhong Mao, Xin Huang, Bing Yang, Xiaojun Ren, Guimin Luo, Jiacong Shen (2004)Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2, 2′-ditellurobis (2-deoxy-beta-cyclodextrin).
Journal of the American Chemical Society 126(50): 16395–16404
2004 Junqiu Liu, Kun Zhang, Xiaojun Ren, Guimin Luo, Jiacong Shen (2004) Bioimprinted protein exhibits glutathione peroxidase activity.
Analytica Chimica Acta 504 (1): 185-189
2003 Xiaojun Ren*, Gérald Gavory*, Haitao Li*, Liming Ying, David Klenerman, Shankar Balasubramanian (2003) Identification of a new RNA: RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation.
Nucleic Acids Research 31 (22): 6509-6515
*Contributed equally to this work
- Selected as Cover Story in the Issue
2003 Delin You, Xiaojun Ren, Yan Xue, Guimin Luo, Tongshu Yang, Jiacong Shen (2003) A selenium-containing single-chain abzyme with potent antioxidant activity.
European Journal of Biochemistry 270 (21): 4326-4331
2003 Guimin Luo, Xiaojun Ren, Junqiu Liu, Ying Mu, Jiacong Shen (2003) Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly.
Current Medicinal Chemistry 10 (13): 1151-1183
2003 Kun Zhang, Xiaojun Ren, Ying Mu, Yan Xue, Canhui Guo, Ganglin Yan, Guimin Luo, Jiacong Shen
(2003) Synthesis of 2-tellurium bridged cyclodextrin as glutathione peroxidase mimics and its catalytic action.
Chinese Journal of Catalysis 24 (2): 97-102
2003 Ying Mu, Shaowu Lv, Xiaojun Ren, Guanghui Jin, Junqiu Liu, Ganglin Yan, Weijia Li, Jiacong Shen, Guimin Luo (2003) UV-B induced keratinocyte apoptosis is blocked by 2-selenium-bridged beta-cyclodextrin, a GPX mimic.
Journal of Photochemistry and Photobiology B-Biology 69 (1): 7-12
2002 Xiaojun Ren, Per Jemth, Philip G. Board, Guimin Luo, Bengt Mannervik, Junqiu Liu, Kun Zhang, Jiacong Shen (2002) A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase.
Chemistry & Biology 9 (7): 789-794
2002 Xiaojun Ren, Yan Xue, Junqiu Liu, Kun Zhang, Jian Zheng, Guimin Luo, Canhui Guo, Ying Mu, Jiacong Shen (2002) A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity.
ChemBioChem 3 (4): 356-363
2001 Xiaojun Ren, Yan Xue, Kun Zhang, Junqiu Liu, Guimin Luo, Jian Zheng, Ying Mu, Jiacong Shen (2001) A novel dicyclodextrinyl ditelluride compound with antioxidant activity.
FEBS Letters 507 (3): 377-380
2001 Dan Su, Xiaojun Ren, Delin You, Dan Li, Ying Mu, Ganglin Yan, Yan Zhang, Yuanming Luo, Yan Xue, Jiacong Shen, Zi Liu, Guimin Luo (2001) Generation of three selenium-containing catalytic antibodies with high catalytic efficiency using a novel hapten design method.
Archives of Biochemistry and Biophysics 395 (2): 177-184
2001 Xiaojun Ren, Shujuan Gao, Delin You, Hualiang Huang, Zi Liu, Ying Mu, Junqiu Liu, Yan Zhang, Ganglin Yan, Guimin Luo, Tongshu Yang, Jiacong Shen (2001) Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency.
Biochemical Journal 359: 369-374
2001 Dan Su, Delin You, Xiaojun Ren, Guimin Luo, Ying Mu, Ganglin Yan, Yan Xue, Jiacong Shen (2001) Kinetics study of a selenium containing ScFv catalytic antibody that mimics glutathione peroxidase.
Biochemical and Biophysical Research Communications 285 (3): 702-707
2001 Xiaojun Ren, Liquan Yang, Junqiu Liu, Dan Su, Delin You, Chuanpen Liu, Kun Zhang, Guimin Luo, Ying Mu, Ganglin Yan, Jiacong Shen (2001) A novel glutathione peroxidase mimic with antioxidant activity.
Archives of Biochemistry and Biophysics 387 (2): 250-256
2000 Junqiu Liu, Guimin Luo, Xiaojun Ren, Ying Mu, Yan Bai, Jiacong Shen (2000) A bis-cyclodextrin diselenide with glutathione peroxidase-like activity.
Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology 1481 (2): 222-228
2000 Xiaojun Ren, Junqiu Liu, Guimin Luo, Yan Zhang, Yuanming Luo, Ganglin Yan, Jiacong Shen (2000) A novel selenocystine-beta-cyclodextrin conjugate those acts as a glutathione peroxidase mimic.
Bioconjugate Chemistry11 (5): 682-687
