Steven Ingersoll, Abby Trouth, J. Carlos Angel, Xinlong Luo, Axel Espinoza, Joey Wen, Chengjie Zhu, Joseph Tucker, Kalkidan Astatike, Christopher J. Phiel, Hatim Sabaawy, Tatiana G. Kutateladze, Tao P. Wu, Tingting Yao, Chao Lu, Srinivas Ramachandran, and Xiaojun Ren# (2026) Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes
Molecular Cell 2026 March In Press.
Steven Ingersoll, Xiaojun Ren# (2025) Hypoxia-specific transcriptional condensates drive metastasis
Trends in Cell Biology 2025 Jun;35(6):456-458.
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren# (2023) Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
Cell Reports 2023 Sep 26;42(10):113136.
Xiaowei Xu, Xu Hua, Kyle Brown, Xiaojun Ren, Zhiguo Zhang (2022) Mcm2 promotes stem cell differentiation via its ability to bind H3-H4.
Elife 2022 Nov 10:11: e80917.
Yi Zhang, Kyle Brown, Yucong Yu, Ziad Ibrahim, Mohamad Zandian, Hongwen Xuan, Steven Ingersoll, Thomas Lee, Christopher C Ebmeier, Jiuyang Liu, Daniel Panne, Xiaobing Shi, Xiaojun Ren, Tatiana G Kutateladze (2021) Nuclear condensates of p300 formed through the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.
Nature Communications 2021 Jul 29; 12(1):4618.
Kyle Brown, Haralambos Andrianakos, Steven Ingersoll, Xiaojun Ren# (2021) Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins.
Nucleic Acids Research 2021 Jul 9; 49(12):6621-6637.
Samantha Kent, Kyle Brown, Chou-hsun Yang, Njood Alsaihati, Christina Tian, Haobin Wang, Xiaojun Ren# (2020) Phase-separated Transcriptional Condensates Accelerate Target-search Process Revealed by Live-cell Single-molecule Imaging.
Cell Reports 2020 Oct 13; 33: 108248.
Roubina Tatavosian, Samantha Kent, Kyle Brown, Tingting Yao, Huy Nguyen Duc, Thao Ngoc Huynh, Chao Yu Zhen, Brian Ma, Haobin Wang, Xiaojun Ren# (2019) Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.
Journal of Biological Chemistry 2019 Feb 1; 294(5):1451-1463.
- The year in the Journal of Biological Chemistry: 2019. The paper was selected by the JBC to represent the exciting advances in gene regulation in 2019.
- Significant biochemistry papers from 100+ years of JBC. The paper was included in a collection of highlights (a total of 46 papers) published in the JBC during the last Century and beyond.
Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang, Xiaojun Ren# (2018) Live-cell Single-Molecule Dynamics of PcG Proteins Imposed by the DIPG H3.3K27M Mutation.
Nature Communications 2018 May 25; 9(1):2080.
Chao Yu Zhen, Roubina Tatavosian, Thao Ngoc Huynh, Huy Nguyen Duc, Raibatak Das, Marko Kokotovic, Jonathan B Grimm, Luke D Lavis, Jun Lee, Frances J Mejia, Yang Li, Tingting Yao, Xiaojun Ren# (2016) Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets Polycomb Cbx7-PRC1 to chromatin.
eLIFE 2016 Oct 10; 5.
Roubina Tatavosian, Chao Yu Zhen, Huy Nguyen Duc, Maggie M. Balas, Aaron Johnson, Xiaojun Ren# (2015) Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-Molecule Chromatin Immunoprecipitation Imaging.
Journal of Biological Chemistry 2015 290(47):28038-54.
- The Best of Year Article in Gene Regulation in 2015 by the JBC.The paper was honored to be named the best article of the year in gene regulation by JBC in 2015.
Chao Yu Zhen, Huy Nguyen Duc, Marko Kokotovic, Christopher Phiel, Xiaojun Ren# (2014) Cbx2 stably associates with mitotic chromosomes via a PRC2 or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes.
Molecular Biology of the Cell 2014 25(23):3726-39.
Bo Cheng*, Xiaojun Ren*, Tom K Kerppola (2014) KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes.
Molecular and Cellular Biology 2014 34(11):2075-91.
*Contributed equally to this work
- One of the most-read articles in May 2014
