{"id":19,"date":"2012-05-31T18:48:06","date_gmt":"2012-05-31T18:48:06","guid":{"rendered":"http:\/\/pages.charlotte.edu\/shan-yan\/?page_id=19"},"modified":"2025-08-14T11:00:07","modified_gmt":"2025-08-14T15:00:07","slug":"publications","status":"publish","type":"page","link":"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/","title":{"rendered":"2-Publications"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/publications\/lab-map\/\" rel=\"attachment wp-att-813\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"813\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/lab-map\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map.png\" data-orig-size=\"2424,1547\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"lab-map\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-300x191.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-1024x654.png\" class=\"alignnone size-large wp-image-813\" src=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-1024x654.png\" alt=\"lab-map\" width=\"640\" height=\"409\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-1024x654.png 1024w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-300x191.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/lab-map-768x490.png 768w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p><strong>Notes:<\/strong><\/p>\n<p><sup>\u00a7<\/sup>: equal contribution<\/p>\n<p><sup>\u2021<\/sup>: undergraduate student<\/p>\n<p><sup>\u00b6<\/sup>: graduate student<\/p>\n<p><sup>#<\/sup>: postdoctoral fellow\/research associate\/research faculty<\/p>\n<p><sup>*<\/sup>: corresponding author<\/p>\n<p>&gt;&gt;&gt;: preprint<\/p>\n<h3>\u00a0<\/h3>\n<h3><strong>Publications after joining <\/strong><strong>UNC Charlotte (total=n)<br \/><\/strong><\/h3>\n<h3>\u00a0<\/h3>\n<h3>2025<\/h3>\n<p class=\"zfr3Q CDt4Ke \" dir=\"ltr\"><strong><span class=\"C9DxTc \">&gt;&gt;&gt;5<\/span><span class=\"C9DxTc \">5<\/span><span class=\"C9DxTc \">. <\/span><\/strong><span class=\"C9DxTc \">McMahon AM<sup>\u00b6<\/sup>, <\/span><span class=\"C9DxTc \">Zhao H<\/span><sup>#<\/sup><span class=\"C9DxTc \">,Li J, Driscoll G<sup>\u00b6<\/sup>, Matos J<sup>\u00b6<\/sup>, McGhee K<sup>\u00b6<\/sup>, Lyttle J<sup>\u2021<\/sup>, <strong><u>Yan S<\/u><sup>*<\/sup><\/strong>. 2025. <\/span>PARP1 promotes replication-independent DNA double-strand break formation after acute DNA-methylation damage. <span class=\"docsum-journal-citation full-journal-citation\">bioRxiv [Preprint]. 2025 Jul 12: 2025.07.10.663928. (PMCID: PMC12265532; PMID: 40672314) DOI: <a href=\"https:\/\/doi.org\/10.1101\/2025.07.10.663928\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1101\/2025.07.10.663928<\/a>.<\/span><\/p>\n<ul id=\"full-view-identifiers\" class=\"identifiers\"><\/ul>\n<h3>\u00a0<\/h3>\n<h3>2024<\/h3>\n<p class=\"zfr3Q CDt4Ke \" dir=\"ltr\"><strong><span class=\"C9DxTc \">5<\/span><span class=\"C9DxTc \">4<\/span><span class=\"C9DxTc \">. <\/span><\/strong><span class=\"C9DxTc \">Zhao H<\/span><sup>#<\/sup><span class=\"C9DxTc \">, <\/span><span class=\"C9DxTc \">Richardson C<\/span><span class=\"C9DxTc \">, <\/span><span class=\"C9DxTc \">Marriott I, Yang IH,<\/span> <strong><u>Yan S<\/u><\/strong>*<span class=\"C9DxTc \">.<\/span><span class=\"C9DxTc \"> 2024<\/span><span class=\"C9DxTc \">. APE1 is a master regulator of the ATR-\/ATM-mediated DNA damage response. <\/span><span class=\"C9DxTc \">DNA Repair<\/span><span class=\"C9DxTc \">. 144: 103776. (Published online <\/span><span class=\"C9DxTc \">October 19<\/span><span class=\"C9DxTc \">, 2024) (<span class=\"identifier pmc\"><span class=\"id-label\">PMCID: <\/span> PMC11611674<\/span>; <\/span><span class=\"C9DxTc \">PMID: 39461278<\/span><span class=\"C9DxTc \">) DOI:\u00a0 <\/span><a class=\"XqQF9c\" href=\"https:\/\/doi.org\/10.1016\/j.dnarep.2024.103776\" target=\"_blank\" rel=\"noopener\"><span class=\"C9DxTc aw5Odc \">https:\/\/doi.org\/10.1016\/j.dnarep.2024.103776<\/span><\/a><\/p>\n<p><strong>53. <\/strong>Zhao H<sup>#<\/sup>, Li J<sup>#<\/sup>, You Z, Lindsay HD, <strong><u>Yan S<\/u><\/strong>*. 2024. Distinct regulation of ATM signaling by DNA single-strand breaks and APE1. <em>Nature Communications<\/em>. 15 (1): 6517. (Published online August 7, 2024) (PMCID: PMC11306256; <span class=\"identifier pubmed\"><span class=\"id-label\">PMID: <\/span> 39112456<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-50836-6\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41467-024-50836-6<\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Public news release<\/strong> 08\/07\/2024. &#8220;Demystifying APE1: New findings on direct activation of ATM signaling by DNA single-strand breaks&#8221; (Please see the link @ <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1053812\" target=\"_blank\" rel=\"noopener\">Eurekalert<\/a>)<\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1164\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-48-28-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" data-orig-size=\"386,76\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.48.28 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" class=\"alignnone size-medium wp-image-1164\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" alt=\"\" width=\"300\" height=\"59\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png 386w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>52. <\/strong>McMahon A<sup>\u00b6<\/sup>, Zhao J,\u00a0 <strong><u>Yan S<\/u><\/strong>*. <strong>2024<\/strong>. Ubiquitin-mediated regulation of APE2 protein abundance. <em>Journal of Biological Chemistry<\/em>. 300 (6): 107337. (PMCID: <span class=\"identifier pmc\">PMC11157268; <\/span>PMID: <span class=\"identifier pubmed\">38705397<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jbc.2024.107337\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jbc.2024.107337<\/a><\/p>\n<p><strong>51.\u00a0<\/strong><strong><u>Yan S<\/u><\/strong>*, <span class=\"docsum-authors full-authors\">Gaddameedhi S*, Sobol RW*.<\/span> <strong>2024<\/strong>. Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson.\u00a0<em>Environmental and Molecular Mutagenesis<\/em>. 65 (S1): 4-8. (PMCID: <span class=\"identifier pmc\">PMC11110888<\/span>; PMID: <span class=\"identifier pubmed\">38619433<\/span>)\u00a0 DOI:<a href=\"https:\/\/doi.org\/10.1002\/em.22595\" target=\"_blank\" rel=\"noopener\"> https:\/\/doi.org\/10.1002\/em.22595<\/a><\/p>\n<p><strong>50. <\/strong>Suptela AJ, Radwan Y, Richardson C, <strong><u>Yan S<\/u><\/strong>, Afonin KA, Marriott I*. <strong>2024<\/strong>. cGAS mediates the inflammatory responses of human microglial cells to genotoxic DNA damage. <em>Inflammation. <\/em><span class=\"cit\">47 (2): 822-836<\/span><em>. <\/em><span class=\"identifier doi\">(PMCID: <span class=\"identifier pmc\">PMC11073916<\/span>; PMID: <span class=\"identifier pubmed\">38148453)<\/span> DOI: <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01946-8\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s10753-023-01946-8<\/a><\/span><\/p>\n<h3>\u00a0<\/h3>\n<h3>2023<\/h3>\n<p><strong>49. <\/strong>Driscoll G<sup>\u00b6<\/sup>, <strong><u>Yan S<\/u><\/strong>*. <strong>2023<\/strong>. Maintaining chromosome and genome stability by the RPA-RNF20-SNF2H cascade. <em>Proceedings of the National Academy of Sciences of the United States of America<\/em>. 120 (24): e2306455120. (PMCID: PMC10268305; PMID: 37276422). DOI: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2306455120\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1073\/pnas.2306455120<\/a><\/p>\n<p><strong>48. <\/strong>Lin Y<sup>#<\/sup>, Li J<sup>#<\/sup>, Zhao H<sup>#<\/sup>, McMahon A<sup>\u00b6<\/sup>, McGhee K<sup>\u00b6<\/sup>, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>*<\/u><\/span>. <strong>2023<\/strong>. APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response. <em>eLife. <\/em>12: e82324. (PMCID: PMC10202453; PMID: 37216274) \u00a0DOI: <a href=\"https:\/\/doi.org\/10.7554\/eLife.82324\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.7554\/eLife.82324<\/a><\/p>\n<p><strong>47. <\/strong>Li J<sup>#<\/sup>, <strong><u>Yan S<\/u><\/strong><span class=\"docsum-authors full-authors\"><u>*<\/u><\/span>. <strong>2023<\/strong>. Molecular mechanisms of nucleolar DNA damage checkpoint response. <em>Trends in Cell Biology<\/em>. 33 (5): 361-364. (Online published on March 16, 2023) (PMCID: PMC10215988; <span class=\"identifier pubmed\"><span class=\"id-label\">PMID: <\/span> 36933998<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.tcb.2023.02.003\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.tcb.2023.02.003<\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Public release<\/strong> 03\/16\/2023. &#8220;Researchers highlight nucleolar DNA damage response in fight against cancer&#8221; (Please see the link @ <a href=\"https:\/\/www.eurekalert.org\/news-releases\/982996\" target=\"_blank\" rel=\"noopener\">Eurekalert<\/a> or @ <a href=\"https:\/\/inside.charlotte.edu\/news-features\/2023-03-16\/researchers-highlight-new-strategies-fight-against-cancer\" target=\"_blank\" rel=\"noopener\">UNC Charlotte<\/a> )<\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1164\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-48-28-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" data-orig-size=\"386,76\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.48.28 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" class=\"alignnone size-medium wp-image-1164\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" alt=\"\" width=\"300\" height=\"59\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png 386w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>46. <\/strong>McMahon A<sup>\u00b6<\/sup>, Zhao J, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>*<\/u><\/span>. <strong>2023<\/strong>. APE2 catalytic function and synthetic lethality draw attention as a cancer therapy target. <em>NAR Cancer<\/em>. 5 (1):zcad006. (PMCID: <span class=\"identifier pmc\">PMC9900424 <\/span>; PMID: <span class=\"identifier pubmed\">36755963<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1093\/narcan\/zcad006\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/<span class=\"docsum-journal-citation full-journal-citation\">10.1093\/narcan\/zcad006<\/span><\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2022<\/h3>\n<p><strong>45. <\/strong>Li J<sup>#<\/sup>, Zhao H, McMahon A<sup>\u00b6<\/sup>, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>*<\/u><\/span>. <strong>2022<\/strong>. APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus. <em>Nucleic Acids Research.<\/em> 50(18):10503-10525.\u00a0 (PMCID: PMC9561277; PMID: 36200829) (online published October 6, 2022). DOI: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkac853\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/nar\/gkac853<\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Public release<\/strong> 03\/16\/2023. &#8220;Researchers highlight nucleolar DNA damage response in fight against cancer&#8221; (Please see the link @ <a href=\"https:\/\/www.eurekalert.org\/news-releases\/982996\" target=\"_blank\" rel=\"noopener\">Eurekalert<\/a> or @ <a href=\"https:\/\/inside.charlotte.edu\/news-features\/2023-03-16\/researchers-highlight-new-strategies-fight-against-cancer\" target=\"_blank\" rel=\"noopener\">UNC Charlotte<\/a> )<\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1164\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-48-28-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" data-orig-size=\"386,76\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.48.28 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" class=\"alignnone size-medium wp-image-1164\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" alt=\"\" width=\"300\" height=\"59\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png 386w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>44. <span class=\"docsum-authors full-authors\"><u>Yan S*<\/u><\/span><\/strong>, Zhao J*, Kemp M*, Sobol RW*. <strong>2022<\/strong>. Editorial: mechanistic studies of genome integrity, environmental health, and cancer etiology. <em>Frontiers in Cell and Developmental Biology.<\/em> 10: 1026326. (PMCID: PMC9554606; PMID: 36247007) DOI: <a href=\"https:\/\/doi.org\/10.3389\/fcell.2022.1026326\">https:\/\/doi.org\/10.3389\/fcell.2022.1026326<\/a><\/p>\n<p><strong>&gt;&gt;&gt;43.<\/strong> Li J<sup>#<\/sup>, Zhao H<sup>#<\/sup>, McMahon A<sup>\u00b6<\/sup>, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>*<\/u><\/span>. <strong>2022<\/strong>. APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus. <em>bioRxiv<\/em>. (preprint online August 22, 2022)\u00a0 DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2022.08.22.504787\" target=\"_blank\" rel=\"noopener\"><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"> https:\/\/doi.org\/10.1101\/2022.08.22.504787<\/span><\/a><\/p>\n<p><strong>&gt;&gt;&gt;42. <\/strong>Lin Y, Li J<sup>#<\/sup>, Zhao H<sup>#<\/sup>, McMahon A<sup>\u00b6<\/sup>, <strong><span class=\"docsum-authors full-authors\"><u>Yan S*<\/u><\/span><\/strong>. <strong>2022<\/strong>. APE1 recruits ATRIP to ssDNA in an RPA-independent manner to promote the ATR DNA damage response. <em>bioRxiv<\/em>. (preprint online August 12, 2022) DOI: <a href=\"https:\/\/doi.org\/10.1101\/2022.08.12.503732\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1101\/2022.08.12.503732<\/a><\/p>\n<p><strong>41.<\/strong> Sadaf H, Hong H, Maqbool M, Emhoff K, Lin J, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>,<\/u><\/span> Anwer F, and Zhao J. <strong>2022<\/strong>. Multiple myeloma etiology and treatment. <em>Journal of Translational Genetics and Genomics<\/em>. 6:63-83. (online ahead of print January 20, 2022)\u00a0 DOI: <a href=\"https:\/\/doi.org\/10.20517\/jtgg.2021.36\" target=\"_blank\" rel=\"noopener\"><u>https:\/\/doi.org\/<\/u>10.20517\/jtgg.2021.36<\/a><\/p>\n<p><strong>40.<\/strong> Tarannum M, Hossain MA, Holmes B, <span class=\"docsum-authors full-authors\"><u><strong>Yan S<\/strong>,<\/u><\/span> Mukherjee P, Vivero-Escoto JL. <strong>2022<\/strong>. Advanced nanoengineering approach for target-specific, spatiotemporal, and ratiometric delivery of gemcitabine-cisplatin combination for improved therapeutic outcome in pancreatic cancer. <em>Small<\/em>. <span class=\"docsum-journal-citation full-journal-citation\">18(2):e2104449<\/span>. (online ahead of print November 10, 2021). (<span class=\"identifier pmc\"><span class=\"id-label\">PMCID: <\/span> PMC8758547<\/span>; PMID: <span class=\"identifier pubmed\">34758094<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1002\/smll.202104449\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/smll.202104449<\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2021<\/h3>\n<p class=\"CDt4Ke zfr3Q\" dir=\"ltr\"><strong>39.<\/strong> Hossain MA<sup>\u00b6<\/sup>, Lin Y<sup>#<\/sup>, Driscoll G<sup>\u00b6<\/sup>, Li J<sup>#<\/sup>, McMahon A<sup>\u00b6<\/sup>, Matos J<sup>\u00b6<\/sup>, Zhao H<sup>#<\/sup>, Tsuchimoto D, Nakabeppu Y, Zhao J, <strong><u>Yan S<\/u><\/strong>*. <strong>2021<\/strong>. APE2 is a general regulator of the ATR-Chk1 DNA damage response pathway to maintain genome integrity in pancreatic cancer cells. <em>Frontiers in Cell and Developmental Biology<\/em>. 9:738502. (PMCID: <span class=\"identifier pmc\">PMC8593216; <\/span>PMID: <span class=\"identifier pubmed\">34796173<\/span>) DOI: <span class=\" aw5Odc\"><a class=\"XqQF9c\" href=\"https:\/\/www.google.com\/url?q=https%3A%2F%2Fdoi.org%2F10.3389%2Ffcell.2021.738502&amp;sa=D&amp;sntz=1&amp;usg=AFQjCNEKBpVltwoh1fNKoHS8KmKq9xYOsw\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fcell.2021.738502<\/a><\/span><\/p>\n<p><strong>38.<\/strong> Huff LA, <strong><span class=\"docsum-authors full-authors\"><u>Yan S<\/u><\/span><\/strong>, and Clemens MG. <strong>2021<\/strong>. Mechanisms of Ataxia Telangiectasia Mutated (ATM) control in the DNA damage response to oxidative stress, epigenetic regulation, and persistent innate immune suppression following sepsis. <em>Antioxidants<\/em>. 10 (7): 1146. (PMCID: <span class=\"identifier pmc\">PMC8301080; <\/span>PMID: <span class=\"identifier pubmed\">34356379<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.3390\/antiox10071146\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/antiox10071146<\/a><\/p>\n<p><strong>37.<\/strong> <span class=\"docsum-authors full-authors\">Hu Y, Yang C, Amorim T, Maqbool M, Lin J, Li C, Fang C, Xue L, Kwart A, Fang H, Yin M, Janocha AJ, Tsuchimoto D, Nakabeppu Y, Jiang X, Mejia-Garcia A, Anwer F, Khouri J, Qi X, Zheng QY, Yu JS, <strong><u>Yan S<\/u><\/strong>, LaFramboise T, Anderson KC, Herlitz LC, Munshi NC, Lin J, Zhao J.<\/span>. <strong>2021<\/strong>. Cisplatin-mediated upregulation of APE2 binding to MYH9 provokes mitochondrial fragmentation and acute kidney injury. <em>Cancer Research <\/em>(online ahead of print December 7, 2020). 81 (3): 713-723. (<span class=\"identifier pmc\"><span class=\"id-label\">PMCID: PMC7869671; <\/span><\/span>PMID: <span class=\"identifier pubmed\">33288657<\/span>) DOI: <a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1010\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/<span class=\"citation-doi\">10.1158\/0008-5472.CAN-20-1010<\/span><\/a><\/p>\n<p><strong>36.<\/strong> Lin Y<sup>#<\/sup>, McMahon A<sup>\u00b6<\/sup>, Driscoll G<sup>\u00b6<\/sup>, Bullock S, Zhao J, and <strong><u>Yan S<\/u><\/strong>*. <strong>2021<\/strong>. Function and molecular mechanisms of APE2 in genome and epigenome integrity. <em>Mutation Research-Reviews in Mutation Research <\/em>(online ahead of print November 16, 2020). 787 (January\u2013June): 108347. (PMCID: PMC8287789; PMID: 34083046) DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.mrrev.2020.108347\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1016\/j.mrrev.2020.108347<\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2020<\/h3>\n<p><strong>35.<\/strong> Ha A<sup>\u00b6<\/sup>, Lin Y<sup>#<\/sup>, and <strong><u>Yan S<\/u><\/strong>*. <strong>2020<\/strong>. A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage. <em>Journal of Biological Chemistry<\/em> (online ahead of print August 14, 2020). 295 (41): 14222-14235. (PMCID: <span class=\"identifier pmc\">PMC7549043; <\/span>PMID: 32817342) DOI: <a href=\"https:\/\/doi.org\/10.1074\/jbc.RA120.014228\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1074\/jbc.RA120.014228<\/a> <cite><\/cite><\/p>\n<p><strong><sup>\u266a<\/sup>Prakash A and Sharma N:<\/strong> Faculty Opinions Recommendation of [Ha A et al., J Biol Chem 2020 295(41):14222-14235]. In Faculty Opinions, 16 Dec 2020; DOI: <a href=\"http:\/\/doi.org\/10.3410\/f.738528228.793580924\" target=\"_blank\" rel=\"noopener\">http:\/\/doi.org\/10.3410\/f.738528228.793580924<\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1162\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-43-31-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" data-orig-size=\"271,46\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.43.31 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" class=\"alignnone size-full wp-image-1162\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" alt=\"\" width=\"271\" height=\"46\" \/><\/a><\/p>\n<p><strong>34. <u>Yan S<\/u><\/strong>* and Vaziri C*. <strong>2020<\/strong>. An introduction for the special issue on environmental health and genome integrity. <em>Environmental and Molecular Mutagenesis<\/em>., 61 (7): 660-663. (PMCID: PMC7442621; PMID:32683747; online ahead of print July 19, 2020)\u00a0 DOI: <a href=\"https:\/\/doi.org\/10.1002\/em.22400\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1002\/em.22400<\/a><\/p>\n<p><strong>33.<\/strong>\u00a0Jensen KA<sup>\u00b6<\/sup>, Shi X,<strong><u> Yan S<\/u><\/strong>*. <strong>2020<\/strong>. Genomic alterations and abnormal expression of APE2 in multiple cancers. <em>Scientific Reports<\/em>, 10 (1): 3758. (PMCID: PMC7048847; PMID:32111912)\u00a0 DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41598-020-60656-5\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1038\/s41598-020-60656-5<\/a><\/p>\n<p><strong>&gt;&gt;&gt;32.<\/strong>\u00a0Jensen KA<sup>\u00b6<\/sup>, Shi X,<strong><u> Yan S<\/u><\/strong>*. <strong>2020<\/strong>. Genomic alterations and abnormal expression of APE2 in multiple cancers. <em>bioRxiv<\/em> (preprint online January 24, 2020) DOI: <a href=\"https:\/\/doi.org\/10.1101\/2020.01.17.910646\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1101\/2020.01.17.910646<\/a><\/p>\n<p><strong>31. <u>Yan S<\/u><\/strong>*., Williams C, and Huet Y. <strong>2020<\/strong>. On the reproducibility of methods or findings. <em>Lab Animal.<\/em> 49 (29-31): 29. (PMCID: PMC7000164; PMID:31988408) DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41684-019-0461-0\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1038\/s41684-019-0461-0<\/a><\/p>\n<p><strong>30.<\/strong> Lin Y<sup>\u00a7<\/sup><sup>,<\/sup><sup>#<\/sup>, Raj J<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u2021<\/sup>, Li J<sup>#<\/sup>, Ha A<sup>\u00b6<\/sup>, Hossain MA<sup>\u00b6<\/sup>, Richardson C, Mukherjee P,<strong> <u>Yan S<\/u><\/strong>*. <strong>2020<\/strong>. APE1 senses DNA single-strand breaks for repair and signaling. <em>Nucleic Acids Research<\/em>. 48(4):1925-1940. (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkz1175\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1093\/nar\/gkz1175<\/a><\/p>\n<p><strong><sup>\u266a<\/sup>Maiorano D<\/strong>: F1000Prime Recommendation of [Lin Y et al., <span class=\"journalname\">Nucleic Acids Res <\/span> <span class=\"pubdate\">2019<\/span>]. In F1000Prime, 03 Jan 2020; DOI: <a href=\"https:\/\/doi.org\/10.3410\/f.737076253.793568982\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3410\/f.737076253.793568982<\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1162\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-43-31-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" data-orig-size=\"271,46\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.43.31 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" class=\"alignnone size-full wp-image-1162\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.43.31-PM.png\" alt=\"\" width=\"271\" height=\"46\" \/><\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2019<\/h3>\n<p><strong>29.<\/strong> Cupello S<sup>\u00b6<\/sup>, Lin Y<sup>#<\/sup>, <strong><u>Yan S<\/u><\/strong>*. <strong>2019<\/strong>. Distinct roles of XRCC1 in genome integrity in <em>Xenopus<\/em> egg extracts. <em>Biochemical Journal<\/em>. <span class=\"volume\">476<\/span><span class=\"issue\">(24)<\/span><span class=\"pages\">:3791-3804<\/span>. (PMCID: PMC6959006; PMID: 31808793) DOI: <a href=\"https:\/\/doi.org\/10.1042\/BCJ20190798\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1042\/BCJ20190798<\/a><\/p>\n<p><strong>28. <u>Yan S<\/u><\/strong>*. <strong>2019<\/strong>. Resolution of a complex crisis at DNA 3\u2032 termini. <em>Nature Structural &amp; Molecular Biology<\/em>. 26 (5): 335-336. (PMCID: PMC6549488; PMID: 30988507) DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41594-019-0215-0\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1038\/s41594-019-0215-0<\/a><\/p>\n<p><strong>27.<\/strong><sup>\u00a0 <\/sup>Lin Y<sup>#<\/sup>, Ha Anh<sup>\u00b6<\/sup><sup>\u2021<\/sup>, <strong><u>Yan S<\/u><\/strong>*. <strong>2019<\/strong>. Methods for studying DNA single-strand break repair and signaling in <em>Xenopus <\/em>egg extracts. <em>Methods in Molecular Biology: DNA Repair Methods and Protocols<\/em>.\u00a0 1999: 161-172. (PMCID: PMC6550457; PMID: 31127575) (Balakrishnan and Stewart eds). DOI: <a href=\"https:\/\/doi.org\/10.1007\/978-1-4939-9500-4_9\">https:\/\/doi.org\/10.1007\/978-1-4939-9500-4_9<\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2016-2018<\/h3>\n<p><strong>26.<\/strong><sup>\u00a0 <\/sup>Hossain MA<sup>\u00b6<\/sup>, Lin Y<sup>#<\/sup>, <strong><u>Yan S<\/u><\/strong>*. <strong>2018<\/strong>. SSB end resection in genome stability: mechanism and regulation by APE2. <em>International Journal of Molecular Sciences<\/em>. 19 (8): 2389.\u00a0 (PMCID: PMC6122073; PMID:30110897) DOI: <a href=\"https:\/\/doi.org\/10.3390\/ijms19082389\">https:\/\/doi.org\/10.3390\/ijms19082389<\/a><\/p>\n<p><strong>25.<\/strong><sup>\u00a0\u00a0<\/sup>Lin Y<sup>\u00a7<\/sup><sup>,<\/sup><sup>#<\/sup>, Bai L<sup>\u00a7,<\/sup><sup>#<\/sup>, Cupello S<sup>\u00b6<\/sup>, Hossain MA<sup>\u00b6<\/sup>, Deem B<sup>\u00b6<\/sup>, McLeod M<sup>\u00b6<\/sup>, Raj J<sup>\u2021<\/sup>, <strong><u>Yan S<\/u><\/strong>*. <strong>2018<\/strong>. APE2 promotes DNA damage response pathway from a single-strand break. <em>Nucleic Acids Research<\/em>. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gky020\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1093\/nar\/gky020<\/a><\/p>\n<p><strong>24.<\/strong><sup>\u00a0 <\/sup>Liu SY<sup>\u00a7<\/sup>, Li X<sup>\u00a7<\/sup>, Lin ZM, Su L, <strong><u>Yan S<\/u><\/strong><sup>*<\/sup>, Zhao B<sup>*<\/sup>, Miao J<sup>*<\/sup>. <strong>2018<\/strong>. SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis. <em>Cancer Letters<\/em>. 416: 11-23. (PMCID: PMC5777349; PMID: 29247827) DOI: <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383517307747\">10.1016\/j.canlet.2017.12.008<\/a><\/p>\n<p><strong>23.<\/strong><sup>\u00a0 <\/sup>Li Z, Li J, Kong Y, <strong><u>Yan S<\/u><\/strong>, Ahmad N, Liu X<sup>*<\/sup>. <strong>2017<\/strong>. Plk1 phosphorylation of Mre11 antagonizes DNA damage response. <em>Cancer Research<\/em>. 77(12): 3169-3180. (PMCID: PMC5504882; PMID: 28512243) DOI: <a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-2787\">10.1158\/0008-5472.CAN-16-2787<\/a><\/p>\n<p><strong>22.<\/strong><sup>\u00a0<\/sup>Wallace BD<sup>\u00a7<\/sup>, Berman Z<sup>\u00a7<\/sup><sup>, \u00b6<\/sup>, Mueller GA, Lin Y<sup>#<\/sup>, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>, Williams RS<sup>*<\/sup>. <strong>2017.\u00a0 <\/strong>APE2 Zf-GRF facilitates 3&#8242;-5&#8242; resection of DNA damage following oxidative stress. <em>Proceedings of the National Academy of Sciences of the United States of America<\/em>. 114 (2): 304-309. (PMCID: PMC5240719; PMID: 28028224) DOI: <a href=\"http:\/\/www.pnas.org\/content\/early\/2016\/12\/20\/1610011114.abstract\"><span class=\"doi\">10.1073\/pnas.1610011114<\/span><\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Public release <\/strong>by Hathaway, J. 01\/06\/2017. Study characterizes key molecular tool in DNA repair enzymes. (Please see the link @ <a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2017-01\/uonc-sck010617.php\">Eurekalert <\/a>or @ <a href=\"http:\/\/publicrelations.uncc.edu\/news-events\/news-releases\/study-characterizes-key-molecular-tool-dna-repair-enzymes\">UNC Charlotte<\/a> )<\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1164\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-48-28-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" data-orig-size=\"386,76\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.48.28 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" class=\"alignnone size-medium wp-image-1164\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" alt=\"\" width=\"300\" height=\"59\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png 386w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>21. <\/strong>Acevedo J, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Michael WM<sup>*<\/sup>.\u00a0<strong>2016<\/strong>. Direct binding of RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage. <em>Journal of Biological Chemistry<\/em>. 291 (25): 13124-13131. (PMCID: PMC4933228; PMID: 27129245) <span class=\"highwire-cite-metadata-doi highwire-cite-metadata\">DOI: <a href=\"http:\/\/dx.doi.org\/10.1074\/jbc.M116.729194\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1074\/jbc.M116.729194<\/a> <\/span>(or @BioRxiv <span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><a href=\"http:\/\/dx.doi.org\/10.1101\/050013\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1101\/050013<\/a>)<br \/><\/span><\/p>\n<p>&gt;&gt;&gt; <strong>20.<\/strong> Acevedo J, <strong><u>Yan S<\/u><\/strong>, Michael WM*.\u00a0<strong>2016<\/strong>. Direct binding of RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage. <em>bioRxiv<\/em>. (preprint online April 23, 2016) DOI: <a href=\"http:\/\/dx.doi.org\/10.1101\/050013\">http:\/\/dx.doi.org\/10.1101\/050013<\/a><\/p>\n<p><strong>19. <\/strong>Cupello S<sup>\u00b6<\/sup>, Richardson C, and <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>. <strong>2016<\/strong>. Cell-free <em>Xenopus<\/em> egg extracts for studying DNA damage response pathways. <em>International Journal of Developmental Biology<\/em>. 60 (7-8-9): 229-236. (PMCID: PMC5071109; PMID: 27160070) DOI: <a href=\"http:\/\/www.ijdb.ehu.es\/web\/paper\/160113sy\/cell-free-xenopus-egg-extracts-for-studying-dna-damage-response-pathways\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1387\/ijdb.160113sy<\/a><\/p>\n<h3>\u00a0<\/h3>\n<h3>2010-2015<\/h3>\n<p><strong>18. <span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>. <strong>2015<\/strong>. Teaching and learning in a <em>Xenopus<\/em> research lab. <em>Lab Animal<\/em>. 44 (8): 327. (PMCID: PMC4545573; PMID: 26200089) DOI: <u>10.1038\/laban.817<\/u><\/p>\n<p><strong>17.<\/strong> DeStephanis D<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u00b6<\/sup>, McLeod M<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u00b6<\/sup>, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>. <strong>2015<\/strong>. REV1 is important for the ATR-Chk1 DNA damage response pathway in <em>Xenopus<\/em> egg extracts. <em>Biochemical and Biophysical Research Communications<\/em>. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X15005239\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">http:\/\/dx.doi.org\/10.1016\/j.bbrc.2015.03.077<\/span><\/a><\/p>\n<p><strong>16.<\/strong> Richardson C<sup>*<\/sup>, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Vestal CG<sup>\u00b6<\/sup>. <strong>2015<\/strong>.\u00a0 Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cells. <em>International Journal of Molecular Sciences<\/em>. 16 (2): 2366-2385. (PMCID: PMC4346841; PMID: 25622253) DOI: <a title=\"http:\/\/dx.doi.org\/10.3390\/ijms16022366\" href=\"http:\/\/dx.doi.org\/10.3390\/ijms16022366\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.3390\/ijms16022366<\/a><\/p>\n<p><strong>15. <span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>, Sorrell M, Berman Z<sup>\u00b6<\/sup>. <strong>2014<\/strong>. Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. <em>Cellular and Molecular Life Sciences<\/em>. 71 (20): 3951-3967. (PMCID: PMC4176976; PMID: 24947324) DOI: <a title=\"http:\/\/dx.doi.org\/10.1007\/s00018-014-1666-4\" href=\"http:\/\/dx.doi.org\/10.1007\/s00018-014-1666-4\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1007\/s00018-014-1666-4<\/a><\/p>\n<p><strong>14.<\/strong> Bai L<sup>#<\/sup>, Michael WM, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>. <strong>2014. <\/strong>Importin \u03b2-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in <i>Xenopus <\/i>egg extracts. <em>Cellular Signalling<\/em>. 26 (5): 857-867. (PMCID: PMC3951582; PMID: 24440306) DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.cellsig.2014.01.006\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1016\/j.cellsig.2014.01.006<\/a><\/p>\n<p><strong>13.<\/strong><sup>\u00a0<\/sup>Willis J<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u00b6<\/sup>, Patel Y<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u2021<\/sup>, Lentz B<sup> \u2021<\/sup>,\u00a0 <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>. <strong>2013.<\/strong>\u00a0APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. <em>Proceedings of the National Academy of Sciences of the United States of America<\/em>. 110 (26): 10592-10597. (PMCID: PMC3696815; PMID: 23754435).\u00a0 DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1073\/pnas.1301445110\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1073\/pnas.1301445110<\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Public release <\/strong>by Hathaway, J. 06\/14\/2013. New Findings Regarding DNA Damage Checkpoint Mechanism in Oxidative Stress. (Please see the link @ <a href=\"http:\/\/publicrelations.uncc.edu\/news-events\/news-releases\/new-findings-regarding-dna-damage-checkpoint-mechanism-oxidative-stress\" target=\"_blank\" rel=\"noopener noreferrer\">UNC Charlotte<\/a> and @ <a href=\"http:\/\/www.eurekalert.org\/pub_releases\/2013-06\/uonc-nfr061413.php\" target=\"_blank\" rel=\"noopener noreferrer\">Eurekalert)<\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1164\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/screen-shot-2020-12-16-at-3-48-28-pm\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" data-orig-size=\"386,76\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen Shot 2020-12-16 at 3.48.28 PM\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png\" class=\"alignnone size-medium wp-image-1164\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png\" alt=\"\" width=\"300\" height=\"59\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM-300x59.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/12\/Screen-Shot-2020-12-16-at-3.48.28-PM.png 386w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Featured<\/strong> by Per, H. 2013. Biochemistry new response mechanism to oxidative stress. <em>Biofutur. <\/em>(346):17-17. (<a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/biofutur-Per.pdf\">Click the link here<\/a>, In French)<\/p>\n<p><strong><sup>\u266a<\/sup> Featured<\/strong> in the UNC-TV Science Week of Review: Reward, June 20, 2013 by Lane, D. (Weblink: <a title=\"UNC-TV\" href=\"http:\/\/science.unctv.org\/content\/week-review-reward\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">http:\/\/science.unctv.org\/content\/week-review-reward<\/span>)<\/a><\/p>\n<p><strong>12. <span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>, Willis J<sup>\u00b6<\/sup>. <strong>2013<\/strong>. WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling. <em>Biochemical and Biophysical Research Communications<\/em>. 431 (2): 466-471. (PMCID: PMC3577970; PMID: 23333389). DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbrc.2012.12.144\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">http:\/\/dx.doi.org\/10.1016\/j.bbrc.2012.12.144<\/span><\/a><\/p>\n<p><strong><sup>\u266a<\/sup> Highlighted<\/strong> on the BBRC website under Article Selections along with an introduction by Dr. Michael Lichten, BBRC Editor with expertise in DNA repair (<a href=\"http:\/\/www.journals.elsevier.com\/biochemical-and-biophysical-research-communications\/article-selections\/promotional-access-to-article-selections-on-dna-repair\/\" target=\"_blank\" rel=\"noopener noreferrer\">Weblink<\/a>).<\/p>\n<p><strong>11.<\/strong> Willis J<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u00b6<\/sup>, DeStephanis D<sup>\u00a7<\/sup><sup>,<\/sup><sup>\u00b6<\/sup>, Patel Y<sup>\u2021<\/sup>, Gowda V<sup>\u2021<\/sup>, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>.<strong>2012<\/strong>. Study of the DNA damage checkpoint using <em>Xenopus<\/em> egg extracts. <em>Journal of Visualized Experiments<\/em>. (69): e4449.\u00a0(PMCID: PMC3514051; PMID: 23149695). DOI: <a href=\"http:\/\/dx.doi.org\/10.3791\/4449\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">http:\/\/dx.doi.org\/<\/span><span style=\"text-decoration: underline\">10.3791\/4449<\/span><\/a><\/p>\n<p><sup>\u266a<\/sup> <strong>Video link:<\/strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3514051\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3514051\/<\/span><\/a><\/p>\n<p><strong>10. <span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>, Huet Y. <strong>2011<\/strong>. Managing a pending IBC approval. Communicate with PI. <em>Lab Animal<\/em>. 40 (10): 295-296. (PMID: 22358201). <span style=\"text-decoration: underline\">DOI: 10.1038\/laban1011-295b<\/span><\/p>\n<p><strong><sup>\u266a<\/sup> Featured<\/strong> by the Office of Laboratory Animal Welfare (OLAW) at the National Institutes of Health (NIH). (<a href=\"http:\/\/grants.nih.gov\/grants\/olaw\/protocol_review.htm\" target=\"_blank\" rel=\"noopener noreferrer\">Please see the link here<\/a>)<\/p>\n<h3>\u00a0<\/h3>\n<h3>\u00a0<\/h3>\n<h3><strong>Publications before joining UNC Charlotte (total=9)<br \/><\/strong><\/h3>\n<p><strong>9.\u00a0\u00a0<\/strong> Van C, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Michael WM, Waga S, Cimprich KA<sup>*<\/sup>. <strong>2010<\/strong>. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. <em>Journal of Cell Biology<\/em>. 189 (2): 233-246. (PMCID: PMC2856894; PMID: 20385778)<\/p>\n<p><strong>8.\u00a0<\/strong> <span style=\"text-decoration: underline\"><strong>Yan S<\/strong>,<\/span> Michael WM<sup>*<\/sup>. <strong>2009<\/strong>. TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation. <em>Cell Cycle<\/em>. 8 (18): 2877-2884. (PMID: 19652550)<\/p>\n<p><strong>7.\u00a0 <span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Michael WM<sup>*<\/sup>. <strong>2009<\/strong>. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. <em>Journal of Cell Biology<\/em>. 184 (6): 793-804.\u00a0 (PMCID: PMC2699152; PMID: 19289795)<\/p>\n<p><strong>6.\u00a0 <span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Lindsay HD, Michael WM<sup>*<\/sup>. <strong>2006<\/strong>. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin-bound Chk1 during checkpoint signaling. <em>Journal of Cell Biology<\/em>. 173 (2): 181-186. (PMCID: PMC2063809; PMID: 16618813)<\/p>\n<p><strong>5.\u00a0 <span style=\"text-decoration: underline\">Yan S<\/span><\/strong><sup>*<\/sup>, Tso J<sup>*<\/sup>. <strong>2004<\/strong>. Temperature may influence and regulate NF-YB expression in toad oocyte. <em>Biochemical and Biophysical Research Communications<\/em><em>.<\/em> 313 (3): 802-811. (PMID: 14697263)<\/p>\n<p><strong>4.\u00a0 <span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Kong WH<sup>*<\/sup>. Gu Z, Zuo JK. <strong>2003<\/strong>. Preparation and preliminary application of monoclonal antibody against cold shock domain of Y-box binding proteins. <em>Journal of Shandong University (Natural Science Edition)<\/em>. 38 (4): 120-124.<\/p>\n<p><strong>3.\u00a0<\/strong> Sun ZG, Kong WH, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Gu Z, Zuo JK<sup>*<\/sup>. <strong>2003<\/strong>. The functions in the progesterone-induced oocyte maturation of toad ubiquitin carboxyl-terminal hydrolase (tUCH) are independent of its UCH activity. <em>Shi Yan Sheng Wu Xue Bao (Acta Biologiae Experimentlis Sinica)<\/em><em>.<\/em> 36 (2): 105-112. (PMID: 12858507)<\/p>\n<p><strong>2.\u00a0<\/strong> Sun ZG, Kong WH, Zhang YJ, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Lu JN, Gu Z, Lin F, Tso JK<sup>*<\/sup>. <strong>2002<\/strong>. A novel ubiquitin carboxyl terminal hydrolase is involved in toad oocyte maturation. <em>Cell Research<\/em>. 12 (3-4): 199-206. (PMID: 12296378)<\/p>\n<p><strong>1.\u00a0<\/strong> Kong WH, <strong><span style=\"text-decoration: underline\">Yan S<\/span><\/strong>, Gu Z, and Tso JK<sup>*<\/sup>. <strong>2002<\/strong>. Developmental stage-dependence of cyclin B1 protein localization and gene expression in rabbit spermatogenesis. <em>Sheng Li Xue Bao (Acta Physiologica Sinica)<\/em>. 54 (5): 400-404. (PMID: 12399820).<\/p>\n<h4>\u00a0<\/h4>\n<p>If you are interested in our publications, please feel free to email Dr. Yan (shan.yan@charlotte.edu).<\/p>\n<p>You can also find our publications from ResearchGate: <a href=\"http:\/\/www.researchgate.net\/profile\/Shan_Yan\/\">http:\/\/www.researchgate.net\/profile\/Shan_Yan\/<\/a><\/p>\n<p>Google Scholar: <a href=\"https:\/\/scholar.google.com\/citations?hl=en&amp;user=7i5iT5EAAAAJ\" target=\"_blank\" rel=\"noopener\">https:\/\/scholar.google.com\/citations?hl=en&amp;user=7i5iT5EAAAAJ<\/a><\/p>\n<p>My Bibliography @NCBI: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/shan.yan.2\/bibliography\/public\/\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/shan.yan.2\/bibliography\/public\/<\/a><\/p>\n<p>ORCID: <a href=\"https:\/\/orcid.org\/0000-0001-8106-6295\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/orcid.org\/0000-0001-8106-6295<\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID.png\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1103\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/orcid\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID.png\" data-orig-size=\"500,500\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"ORCID\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID-300x300.png\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID.png\" class=\"alignnone size-medium wp-image-1103\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID-300x300.png\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID-300x300.png 300w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID-150x150.png 150w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2020\/04\/ORCID.png 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><span style=\"color: #000000\">\u00a0<\/span><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2018\/03\/NAR_cover.gif\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"949\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/nar_cover\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2018\/03\/NAR_cover.gif\" data-orig-size=\"133,172\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"NAR_cover\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2018\/03\/NAR_cover.gif\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2018\/03\/NAR_cover.gif\" class=\"alignnone wp-image-949\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2018\/03\/NAR_cover.gif\" alt=\"\" width=\"188\" height=\"243\" \/><\/a><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"322\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/pnas\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\" data-orig-size=\"133,178\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;}\" data-image-title=\"PNAS\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\" class=\"alignnone wp-image-322\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\" alt=\"PNAS\" width=\"185\" height=\"248\" \/><\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009.jpg\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"286\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/jcb-184-6-2009-2\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009.jpg\" data-orig-size=\"1275,1651\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;}\" data-image-title=\"JCB 184-6-2009\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009-231x300.jpg\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009-790x1024.jpg\" class=\"alignnone wp-image-286\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009-790x1024.jpg\" alt=\"JCB 184-6-2009\" width=\"191\" height=\"248\" srcset=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009-790x1024.jpg 790w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009-231x300.jpg 231w, https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/JCB-184-6-2009.jpg 1275w\" sizes=\"auto, (max-width: 191px) 100vw, 191px\" \/><\/a><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/publications\/cover-cr\/\" rel=\"attachment wp-att-907\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"907\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/cover-cr\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cover-CR.jpg\" data-orig-size=\"166,220\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"cover-CR\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cover-CR.jpg\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cover-CR.jpg\" class=\"alignnone wp-image-907\" src=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cover-CR.jpg\" alt=\"\" width=\"187\" height=\"248\" \/><\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-research-cover3.jpg\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"288\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/cell-research-cover3\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-research-cover3.jpg\" data-orig-size=\"146,186\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;}\" data-image-title=\"cell research-cover3\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-research-cover3.jpg\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-research-cover3.jpg\" class=\"alignnone wp-image-288\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-research-cover3.jpg\" alt=\"cell research-cover3\" width=\"191\" height=\"243\" \/><\/a><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/PNAS.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"http:\/\/www.jbc.org\/content\/291\/25.cover.gif\" alt=\"Cover\" width=\"186\" height=\"244\" \/><\/a><\/p>\n<p><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/00018.jpg\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"680\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/attachment\/00018\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/00018.jpg\" data-orig-size=\"153,209\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"00018\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/00018.jpg\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/00018.jpg\" class=\"alignnone wp-image-680\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/00018.jpg\" alt=\"\" width=\"183\" height=\"250\" \/><\/a><a href=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-cycle.jpg\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"289\" data-permalink=\"https:\/\/pages.charlotte.edu\/shan-yan\/publications\/cell-cycle\/\" data-orig-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-cycle.jpg\" data-orig-size=\"150,194\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;}\" data-image-title=\"cell cycle\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-cycle.jpg\" data-large-file=\"https:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-cycle.jpg\" class=\"alignnone wp-image-289\" src=\"http:\/\/pages.charlotte.edu\/shan-yan\/wp-content\/uploads\/sites\/86\/2012\/05\/cell-cycle.jpg\" alt=\"\" width=\"187\" height=\"242\" \/><\/a><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Notes: \u00a7: equal contribution \u2021: undergraduate student \u00b6: graduate student #: postdoctoral fellow\/research associate\/research faculty *: corresponding author &gt;&gt;&gt;: preprint \u00a0 Publications after joining UNC Charlotte (total=n) \u00a0 2025 &gt;&gt;&gt;55. McMahon AM\u00b6, Zhao H#,Li J, Driscoll G\u00b6, Matos J\u00b6, McGhee K\u00b6, Lyttle J\u2021, Yan S*. 2025. PARP1 promotes replication-independent DNA double-strand break formation after acute [&hellip;]<\/p>\n","protected":false},"author":576,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-19","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P2ssg4-j","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/users\/576"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":471,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/19\/revisions"}],"predecessor-version":[{"id":1559,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/19\/revisions\/1559"}],"wp:attachment":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/media?parent=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}