{"id":23,"date":"2012-05-31T18:52:59","date_gmt":"2012-05-31T18:52:59","guid":{"rendered":"http:\/\/pages.charlotte.edu\/shan-yan\/?page_id=23"},"modified":"2024-06-03T21:40:49","modified_gmt":"2024-06-04T01:40:49","slug":"people","status":"publish","type":"page","link":"https:\/\/pages.charlotte.edu\/shan-yan\/people\/","title":{"rendered":"1-People"},"content":{"rendered":"\n\n\n
\n

PI:\u00a0Dr. Shan Yan<\/strong><\/strong><\/h2>\n

Professor<\/strong>, University of North Carolina at Charlotte, Charlotte, NC, 2019-present<\/p>\n

Associate Professor<\/strong>, University of North Carolina at Charlotte, Charlotte, NC<\/p>\n

Assistant Professor<\/strong>, University of North Carolina at Charlotte, Charlotte, NC<\/p>\n

Research Associate<\/strong>, Harvard University, Cambridge, MA<\/p>\n

Postdoctoral Fellow<\/strong>,\u00a0Harvard University, Cambridge, MA<\/p>\n

Ph.D.<\/strong>, Fudan University, Shanghai, China<\/p>\n

B.S. & M.S.<\/strong>, Shandong University, Jinan, China<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Lab Members<\/strong><\/h2>\n

Research Associate
<\/strong><\/h3>\n

Jia Li<\/strong>, PhD<\/p>\n

Haichao Zhao<\/strong>, PhD<\/p>\n

\u00a0<\/h3>\n

Postdoctoral Fellow<\/strong><\/h3>\n

\u00a0<\/h3>\n

Graduate Students<\/strong><\/h3>\n

Garrett Driscoll<\/strong><\/p>\n

Joshua Matos<\/strong><\/p>\n

Anne McMahon<\/strong><\/p>\n

Kelly McGhee<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Undergraduate Students <\/strong><\/h3>\n

Jade Lyttle: <\/strong>OUR Scholar
<\/strong><\/p>\n

Anthony Malone:<\/strong> OUR Scholar<\/p>\n

\u00a0<\/strong><\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Lab photos<\/strong><\/strong><\/strong><\/h2>\n

\"\"<\/a><\/p>\n

Summer of 2023<\/h3>\n

\"\"<\/a><\/p>\n

Fall of 2020<\/h3>\n

\"labpic-fall2016\"<\/a><\/p>\n

Fall of 2016<\/h3>\n

\u00a0\"lab-10-31-2014\"<\/a><\/h3>\n

Fall of 2014<\/h3>\n

\"summer2013-2\"<\/a><\/h3>\n

Summer of 2013<\/strong><\/h3>\n

\"\"<\/a><\/p>\n

Winter of 2012<\/strong><\/h3>\n
\n

\"\"<\/a><\/p>\n

Summer 2012
<\/strong><\/h3>\n

\u00a0<\/strong><\/h3>\n

\u00a0<\/h3>\n

\u00a0<\/strong><\/h3>\n<\/div>\n

————————————————————————————————————————————<\/p>\n

Former Lab Members<\/strong><\/h2>\n

Research Faculty<\/h3>\n

Yunfeng Lin<\/strong>, PhD (2022-2023): Research Assistant Professor<\/p>\n

\u00a0<\/h4>\n

Postdoctoral Fellow<\/strong><\/h4>\n

Liping Bai, <\/strong>PhD (2012-2014): now Professor @Peking Union Medical College, China
<\/strong><\/p>\n

Yunfeng Lin<\/strong>, PhD (2015-2022)<\/p>\n

Jia Li<\/strong>, PhD (2018-2023)<\/p>\n

\u00a0<\/h4>\n

Graduate Students<\/h4>\n

(8)\u00a0<\/strong>Md. Akram Hossain<\/strong> (2016-2021): PhD. Graduate School Summer Fellowship (2019 & 2020)
<\/strong><\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Hossain MA<\/strong>\u00b6<\/sup>, Lin Y#<\/sup>, Yan S*. 2018<\/strong>. SSB end resection in genome stability: mechanism and regulation by APE2. International Journal of Molecular Sciences<\/em>. 19 (8): 2389.\u00a0 (PMCID: PMC6122073; PMID:30110897) DOI: https:\/\/doi.org\/10.3390\/ijms19082389<\/a><\/p>\n

(b<\/strong>)\u00a0Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Raj J\u00a7<\/sup>,<\/sup>\u2021<\/sup>, Li J#<\/sup>, Ha A\u00b6<\/sup>, Hossain MA<\/strong>\u00b6<\/sup>, Richardson C, Mukherjee P, Yan S*. 2020<\/strong>. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research<\/em>. 48(4):1925-1940 (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: https:\/\/doi.org\/10.1093\/nar\/gkz1175<\/a><\/p>\n

(c<\/strong>) Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Bai L\u00a7,<\/sup>#<\/sup>, Cupello S\u00b6<\/sup>, Hossain MA<\/strong>\u00b6<\/sup>, Deem B\u00b6<\/sup>, McLeod M\u00b6<\/sup>, Raj J\u2021<\/sup>, Yan S*. 2018<\/strong>. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research<\/em>. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https:\/\/doi.org\/10.1093\/nar\/gky020<\/a><\/p>\n

(7) Anh Ha<\/strong> (2018-2020): M.S.,
<\/strong><\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Ha A<\/strong>\u00b6<\/sup>, Lin Y#<\/sup>, and Yan S*. 2020<\/strong>. A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage. Journal of Biological Chemistry<\/em> (online ahead of print August 14, 2020). DOI: https:\/\/doi.org\/10.1074\/jbc.RA120.014228<\/a><\/p>\n

(b<\/strong>)\u00a0Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Raj J\u00a7<\/sup>,<\/sup>\u2021<\/sup>, Li J#<\/sup>, Ha A<\/strong>\u00b6<\/sup>, Hossain MA\u00b6<\/sup>, Richardson C, Mukherjee P, Yan S*. 2020<\/strong>. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research<\/em>. 48(4):1925-1940 (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: https:\/\/doi.org\/10.1093\/nar\/gkz1175<\/a><\/p>\n

(c<\/strong>)\u00a0 <\/sup>Lin Y#<\/sup>, Ha Anh<\/strong>\u00b6<\/sup>\u2021<\/sup>, Yan S*. 2019<\/strong>. Methods for studying DNA single-strand break repair and signaling in Xenopus <\/em>egg extracts. Methods in Molecular Biology: DNA Repair Methods and Protocols<\/em>.\u00a0 1999: 161-172. (PMCID: PMC6550457; PMID: 31127575) (Balakrishnan and Stewart eds). DOI: https:\/\/doi.org\/10.1007\/978-1-4939-9500-4_9<\/a><\/p>\n

(6) Steven Cupello <\/strong>(2014-2019): PhD. Graduate School Summer Fellowship (2018)<\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Cupello S<\/strong>\u00b6<\/sup>, Lin Y#<\/sup>, Yan S*. 2019<\/strong>. Distinct roles of XRCC1 in genome integrity in Xenopus<\/em> egg extracts. Biochemical Journal<\/em>. 476<\/span>(24)<\/span>:3791-3804<\/span>. (PMCID: PMC6959006; PMID: 31808793) DOI: https:\/\/doi.org\/10.1042\/BCJ20190798<\/a><\/p>\n

(b<\/strong>) Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Bai L\u00a7,<\/sup>#<\/sup>, Cupello S<\/strong>\u00b6<\/sup>, Hossain MA\u00b6<\/sup>, Deem B\u00b6<\/sup>, McLeod M\u00b6<\/sup>, Raj J\u2021<\/sup>, Yan S*. 2018<\/strong>. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research<\/em>. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https:\/\/doi.org\/10.1093\/nar\/gky020<\/a><\/p>\n

(c<\/strong>) Cupello S<\/strong>\u00b6<\/sup>, Richardson C, and Yan S*<\/sup>. 2016<\/strong>. Cell-free Xenopus<\/em> egg extracts for studying DNA damage response pathways. International Journal of Developmental Biology<\/em>. 60 (7-8-9): 229-236. (PMCID: PMC5071109; PMID: 27160070) DOI: http:\/\/dx.doi.org\/10.1387\/ijdb.160113sy<\/a><\/p>\n

(5) Melissa McLeod <\/strong>(2014-2016): M.S.. The 2018 Graduate School Outstanding M.S. Thesis Award
<\/strong><\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) DeStephanis D\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, McLeod M<\/strong>\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, Yan S*<\/sup>. 2015<\/strong>. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus<\/em> egg extracts. Biochemical and Biophysical Research Communications<\/em>. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: http:\/\/dx.doi.org\/10.1016\/j.bbrc.2015.03.077<\/a><\/p>\n

(b<\/strong>) Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Bai L\u00a7,<\/sup>#<\/sup>, Cupello S\u00b6<\/sup>, Hossain MA\u00b6<\/sup>, Deem B\u00b6<\/sup>, McLeod M<\/strong>\u00b6<\/sup>, Raj J\u2021<\/sup>, Yan S*. 2018<\/strong>. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research<\/em>. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https:\/\/doi.org\/10.1093\/nar\/gky020<\/a><\/p>\n

(4) Bradley Deem <\/strong>(2014-2015): M.S. transfer to non-thesis track<\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Lin Y\u00a7<\/sup>,<\/sup>#<\/sup>, Bai L\u00a7,<\/sup>#<\/sup>, Cupello S\u00b6<\/sup>, Hossain MA\u00b6<\/sup>, Deem B<\/strong>\u00b6<\/sup>, McLeod M\u00b6<\/sup>, Raj J\u2021<\/sup>, Yan S*. 2018<\/strong>. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research<\/em>. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https:\/\/doi.org\/10.1093\/nar\/gky020<\/a><\/p>\n

(3) Zachary Berman<\/strong>\u00a0 (2013-2015): M.S. student.<\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Wallace BD\u00a7<\/sup>, Berman Z<\/strong>\u00a7<\/sup>, \u00b6<\/sup>,, Mueller GA, Lin Y#<\/sup>, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S*<\/sup>, Williams RS*<\/sup>. 2017.\u00a0 <\/strong>APE2 Zf-GRF facilitates 3\u2032-5\u2032 resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America<\/em>. 114 (2): 304-309. (PMCID: PMC5240719; PMID: 28028224) DOI: 10.1073\/pnas.1610011114<\/span><\/a><\/p>\n

(b<\/strong>) Yan S*<\/sup>, Sorrell M, Berman Z<\/strong>\u00b6<\/sup>. 2014<\/strong>. Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cellular and Molecular Life Sciences<\/em>. 71 (20): 3951-3967. (PMCID: PMC4176976; PMID: 24947324) DOI: http:\/\/dx.doi.org\/10.1007\/s00018-014-1666-4<\/a><\/p>\n

(2) Jeremy Willis<\/strong> (2011-2013): M.S.<\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) Willis J<\/strong>\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, Patel Y\u00a7<\/sup>,<\/sup>\u2021<\/sup>, Lentz B \u2021<\/sup>,\u00a0 Yan S*<\/sup>. 2013.<\/strong>\u00a0APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America<\/em>. 110 (26): 10592-10597. (PMCID: PMC3696815; PMID: 23754435).\u00a0 DOI:\u00a0http:\/\/dx.doi.org\/10.1073\/pnas.1301445110<\/a><\/p>\n

(b<\/strong>) Yan S*<\/sup>, Willis J<\/strong>\u00b6<\/sup>. 2013<\/strong>. WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling. Biochemical and Biophysical Research Communications<\/em>. 431 (2): 466-471. (PMCID: PMC3577970; PMID: 23333389). DOI: http:\/\/dx.doi.org\/10.1016\/j.bbrc.2012.12.144<\/a><\/p>\n

(c<\/strong>) Willis J<\/strong>\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, DeStephanis D\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, Patel Y\u2021<\/sup>, Gowda V\u2021<\/sup>, Yan S*<\/sup>.2012<\/strong>. Study of the DNA damage checkpoint using Xenopus<\/em> egg extracts. Journal of Visualized Experiments<\/em>. (69): e4449.\u00a0(PMCID: PMC3514051; PMID: 23149695). DOI: http:\/\/dx.doi.org\/10.3791\/4449<\/a><\/p>\n

(1) Darla DeStephanis <\/strong>(2010-2013): M.S.<\/p>\n

Publications:<\/strong><\/p>\n

(a<\/strong>) DeStephanis D<\/strong>\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, McLeod M\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, Yan S*<\/sup>. 2015<\/strong>. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus<\/em> egg extracts. Biochemical and Biophysical Research Communications<\/em>. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: http:\/\/dx.doi.org\/10.1016\/j.bbrc.2015.03.077<\/a><\/p>\n

(b<\/strong>) Willis J\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, DeStephanis D<\/strong>\u00a7<\/sup>,<\/sup>\u00b6<\/sup>, Patel Y\u2021<\/sup>, Gowda V\u2021<\/sup>, Yan S*<\/sup>.2012<\/strong>. Study of the DNA damage checkpoint using Xenopus<\/em> egg extracts. Journal of Visualized Experiments<\/em>. (69): e4449.\u00a0(PMCID: PMC3514051; PMID: 23149695). DOI: http:\/\/dx.doi.org\/10.3791\/4449<\/a><\/p>\n

\u00a0<\/h4>\n

\u00a0<\/h4>\n

Undergraduate Students<\/strong><\/h4>\n
\n

(24) Amogh Bandekar: <\/strong>Levine Scholar<\/p>\n

(23) Brianna Bush:<\/strong> Charlotte Research Scholar
<\/strong><\/p>\n

(22)<\/strong> Kyleigh Payne:<\/strong> OUR Scholar<\/p>\n

(21) Naya Kayali <\/strong>(2020-2021):<\/span>
<\/span><\/p>\n

(20)\u00a0<\/strong>Amit Thota <\/strong>(2019-2020): Charlotte Research Scholar<\/span><\/p>\n

(19) Adam Dignan <\/span><\/strong>(2019):<\/span> Charlotte Research Scholar<\/span>
<\/span><\/strong><\/p>\n

(18) Emily Floyd <\/span><\/strong>(2018-2019):<\/span><\/p>\n

(17) Katherine Jensen <\/span><\/strong>(2017-2018): <\/span>Charlotte Research Scholar, ANSWER Scholar<\/span>
<\/span><\/strong><\/p>\n

(16) Anh Ha <\/strong>(2016-2018): NSF REU Fellow<\/p>\n

(15) Mary Tess<\/span> Overton <\/strong>(2015-2018): Barry Goldwater Scholar, NSF REU Fellow<\/p>\n

(14) Victoria Fitts<\/strong> (2016): NSF REU Fellow, undergraduate student from Santa Fe College<\/p>\n

(13) Jude Raj<\/strong> (2013-2016): NSF REU Fellow, Honors student<\/p>\n

(12) Dafe<\/span> Omerhi <\/strong>(2015-2016):
<\/strong><\/p>\n

(11)\u00a0Krystal Carmichael<\/strong><\/strong> (2014-2015): Charlotte Research Scholar, Honors student<\/p>\n

(10) Harleen Kaur<\/strong> (2013-2014):
<\/strong><\/p>\n

(9)\u00a0 Peyman \u201cAlex\u201d Gharavizadeh <\/strong><\/strong>(2014):<\/p>\n

(8) \u00a0Jagat Patel<\/strong> (2013):<\/p>\n

(7)<\/strong>\u00a0 Alexa R. Campbell\u00a0<\/strong>(2013): undergraduate student from UNC-Chapel Hill<\/p>\n

(6)\u00a0 <\/strong>James Hooper <\/strong>(2012):<\/p>\n<\/div>\n

(5)\u00a0 Mallorie Hartmann <\/strong><\/strong><\/strong>(2012-2013):<\/div>\n

(4)\u00a0 <\/strong>Mohammad Ahmad <\/strong>(2012):
<\/strong><\/p>\n

(3)\u00a0 Yogin Patel <\/strong><\/strong><\/strong>(2011-2012): Honors student<\/div>\n

(2)\u00a0 Barry Lentz<\/strong><\/strong><\/strong> (2011): Honors student<\/p>\n

(1)\u00a0 Vrushab Gowda <\/strong><\/strong>(2010-2012): Levine Scholar<\/p>\n

Post-Bac student<\/strong><\/h4>\n

(1) John Curtis Dukes<\/strong> (2011):

<\/strong><\/p>\n

High School Students<\/strong><\/h4>\n

Vijay Rachakonda<\/strong><\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

PI:\u00a0Dr. Shan Yan Professor, University of North Carolina at Charlotte, Charlotte, NC, 2019-present Associate Professor, University of North Carolina at Charlotte, Charlotte, NC Assistant Professor, University of North Carolina at Charlotte, Charlotte, NC Research Associate, Harvard University, Cambridge, MA Postdoctoral Fellow,\u00a0Harvard University, Cambridge, MA Ph.D., Fudan University, Shanghai, China B.S. & M.S., Shandong University, Jinan, […]<\/p>\n","protected":false},"author":576,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P2ssg4-n","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/users\/576"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":178,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":1457,"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/pages\/23\/revisions\/1457"}],"wp:attachment":[{"href":"https:\/\/pages.charlotte.edu\/shan-yan\/wp-json\/wp\/v2\/media?parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}