Peer-Reviewed Publications (last update – September 2023)
- Goad DW, Nesmelova AY, Yohe LR, *Grdzelishvili V.Z. (2023) “Intertumoral heterogeneity impacts oncolytic vesicular stomatitis virus efficacy in mouse pancreatic cancer cells” Journal of Virology 2023 Sep 6:e0100523. doi: 10.1128/jvi.01005-23. [PMID: 37671865]
- Goad D.W., Bressy C., Holbrook M.C., and Grdzelishvili VZ. 2021 “Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus” Molecular Therary Oncolytics. 2021 24:59-76. doi: 10.1016/j.omto.2021.11.019. [PMID: 34977342]
- Holbrook M.C., Goad D.W., and Grdzelishvili VZ. 2021 “Expanding the Spectrum of Pancreatic Cancers Responsive to Vesicular Stomatitis Virus-Based Oncolytic Virotherapy: Challenges and Solutions” Cancers (Basel). 2021 Mar 9;13(5):1171. doi: 10.3390/cancers13051171. [PMID: 33803211]
- Seegers S.L., Frasier C., Greene S., Nesmelova I.V., and Grdzelishvili VZ. 2019 “Experimental Evolution Generates Novel Oncolytic Vesicular Stomatitis Viruses With Improved Replication in Virus-Resistant Pancreatic Cancer Cells”. Journal of Virology, 2020 Jan 17;94(3):e01643-19. doi: 10.1128/JVI.01643-19. [PMID: 31694943]
- Bressy C, Droby GN, Maldonado BD, Steuerwald N, and Grdzelishvili VZ. 2019 “Cell Cycle Arrest in G(2)/M Phase Enhances Replication of Interferon-Sensitive Cytoplasmic RNA Viruses via Inhibition of Antiviral Gene Expression”. Journal of Virology, 2019 Feb 5;93(4). pii: e01885-18. doi: 10.1128/JVI.01885-18 [PMID: 30487274]
- Felt S.A. and Grdzelishvili V.Z. 2017 “Recent advances in vesicular stomatitis virus-based oncolytic virotherapy: a 5-year update” Journal of General Virology, 98: 2895-2911, doi: 10.1099/jgv.0.000980. [PMID: 29143726]
- Felt S.A., Droby G.N., Grdzelishvili V.Z. 2017 “Ruxolitinib and polycation combination treatment overcomes multiple mechanisms of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus” Journal of Virology, 2017, 91(16)
- Bressy C, Hastie E, Grdzelishvili VZ. 2017 “Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy” Molecular Therary Oncolytics. 2017 5:20-40
- Hastie E., Cataldi M., Moerdyk-Schauwecker M.J., Felt S.A., Steuerwald N.,Grdzelishvili V.Z. 2016 “Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus” Oncotarget. 2016 doi: 10.18632/oncotarget.11202
- Cataldi M., Shah N.R., Felt S.A., Grdzelishvili V.Z. 2015 “Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1”. Virology. 2015 485:340-354. [PMID: 26331681]
- Hastie E., Cataldi M., Steuerwald N., and *Grdzelishvili V.Z. 2015 “An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells” Virology. 483:126-140. [PMID: 25965802]
- Sanjuan R. and Grdzelishvili V.Z. 2015 “Evolution of oncolytic viruses”, Current Opinion in Virology, 2015, 13:1-5 [PMID:25699475]
- Felt S.A., Moerdyk-Schauwecker M., and Grdzelishvili V.Z. 2015 “Induction of apoptosis in pancreatic cancer cells by vesicular stomatitis virus“, Virology, 474:163-173 [PMID:25463614]
- Moerdyk-Schauwecker M., Hwang S. and Grdzelishvili V.Z. 2014 “Cellular proteins associated with the interior and exterior of vesicular stomatitis virus visions” PLoS One, 9(8):e104688 [PMID:25105980]
- Hastie E., Besmer D.M., Shah N.R., Murphy A., Moerdyk-Schauwecker M., Molestina C., Roy L., Curry J.M., Mukherjee P., and Grdzelishvili V.Z. 2013 “Oncolytic vesicular stomatitis virus in immunocompetent model of MUC1 positive and MUC1 null pancreatic ductal adenocarcinoma”, Journal of Virology, 87:10283-94. [PMID: 23864625]
- Hastie E., Cataldi M., Marriott I., and Grdzelishvili V.Z. 2013 “Understanding and Altering Cell Tropism of Vesicular Stomatitis Virus“. Virus Research. 176:16-32 [PubMed PMID: 23796410]
- Curry J.M., Thompson K.J., Rao S.G., Besmer D.M., Murphy A.M., Grdzelishvili V.Z., Ahrens W.A., McKillop I.H., Sindram D., Iannitti D.A., Martinie J.B., Mukherjee P. 2013 “The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer“, Journal of Surgical Oncology. 107:713-22. [PubMed PMID: 23335066]
- Moerdyk-Schauwecker M., Shah N.R. Murphy A.M., Hastie, E., Mukherjee, P., and Grdzelishvili V.Z. 2013 “Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: role of type I interferon signaling”, Virology, 436:221-34 [PMID:23246628]
- Hastie E. and Grdzelishvili V.Z. 2012 “Vesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancer” Journal of General Virology, 93:2529-45. [PMID:23052398]
- Murphy A. M., Besmer D. M., Moerdyk-Schauwecker M., Moestl N., Ornelles D., Mukherjee P., and Grdzelishvili V. Z. 2012 “Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma” Journal of Virology, 86:3073-87. [PMID: 22238308]
- Moerdyk-Schauwecker M., Destephanis D., Hastie E, and Grdzelishvili V.Z. 2011 “Detecting Protein-Protein Interactions in Vesicular Stomatitis Virus Using a Cytoplasmic Yeast Two Hybrid System. Journal of Virological Methods. 173, 203-12. [PMID: 21320532]
- Murphy A.M., Moerdyk-Schauwecker M., Mushegian A., and Grdzelishvili V.Z. 2010 “Sequence-Function Analysis of the Sendai virus L protein domain VI” Virology, 405(2), 370-82. [PMID: 20609457]
- Shah N., Sunderland A., Grdzelishvili V.Z. 2010 “Cell Type Mediated Resistance of Vesicular Stomatitis Virus and Sendai Virus to Ribavirin“, PLoS One, 5(6):e11265. [PMID: 20582319]
- Furr S.R., Moerdyk-Schauwecker M., Grdzelishvili V.Z., and Marriott I. 2010 “RIG-I Mediates Nonsegmented Negative-Sense RNA Virus-Induced Inflammatory Immune Responses of Primary Human Astrocytes” Glia, 58:1620-9, [PMID: 20578054]
- Chauhan V.S., Sterka D.G. Jr., Furr S.R., Marriott I. and Grdzelishvili V.Z. 2010 “Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses” Virology, 400:187-96.
- Moerdyk-Schauwecker M., Hwang S. and Grdzelishvili V.Z. 2009 “Analysis of virion associated host proteins in vesicular stomatitis virus using a proteomics approach” Virology Journal, 6:166.
- Murphy A.M. and Grdzelishvili V.Z. 2009 “Identification of Sendai Virus L Protein Amino Acid Residues Affecting Viral mRNA Cap Methylation” Journal of Virology, 83:1669-81.
- Furr S.R., Chauhan V.S., Sterka D.Jr., Grdzelishvili V., and Marriott I. 2008 “Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus”, Journal of Neurovirology, 14: 503 – 513.
- Grdzelishvili V.Z., Smallwood S., Tower D., Hall R.L., Hunt D.M., and Moyer S.A. 2006 “Identification of a new region in the vesicular stomatitis virus L protein which determines defects in mRNA cap methylation”, Virology, 350, 394-405
- Grdzelishvili V.Z., Smallwood S., Tower D., Hall R.L., Hunt D.M., and Moyer S.A. 2005 “A single amino acid change in the L polymerase protein of vesicular stomatitis virus completely abolishes viral mRNA cap methylation”, Journal of Virology, 79, 7327-7337
- Grdzelishvili V.Z., Garcia-Ruiz H., Watanabe T., and Ahlquist P. 2005 “Mutual interference between genomic RNA replication and subgenomic RNA transcription in brome mosaic virus”, Journal of Virology, 79, 1438-1451
- Kushner D.B, Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., and Ahlquist P. 2003 “Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus”, Proc. Natl. Acad. Sci. USA, 100, 15764-15769
- Grdzelishvili V.Z., Chapman S.N., Dawson W.O. and Lewandowski D.J. 2000 “Mapping of the tobacco mosaic virus movement protein and coat protein subgenomic RNA promoters in vivo”, Virology, 275, 177-192
- Solovyev, A. G., Savenkov E. I., Grdzelishvili V. Z., Kalinina N. O., Morozov S. Y., Schiemann J., and Atabekov J. G. 1999 “Movement of hordeivirus hybrids with exchanges in the triple gene block”, Virology, 253, 278-287
- Solovyev, A. G., Zelenina D. A., Savenkov E. I., Grdzelishvili V. Z., Morozov S. Y., Maiss E., Casper R., and Atabekov J. G.. 1997 “Host-controlled cell-to-cell movement of a hybrid barley stripe mosaic virus expressing a dianthovirus movement protein”, Intervirology, 40,1-6
- Solovyev, A. G., Zelenina D. A., Savenkov E. I., Grdzelishvili V. Z., Morozov S. Y., Lesemann D. E., Maiss E., Casper R., and Atabekov J. G.. 1996 “Movement of a barley stripe mosaic virus chimera with a tobacco mosaic virus movement protein”, Virology, 217, 435-441.