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TRUMAN LAB
TRUMAN LAB
ROLE OF MOLECULAR CHAPERONES IN CANCER
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Office: Woodward 486C
Phone: 704-687-5228
Email: atruman1@uncc.edu
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Home

The Truman Lab has moved sites! Please see:

Trumanlab.org

For undergraduate, graduate or postdoctoral research opportunities, please see here:

Research Opportunities

Hsp70 and Hsp90 are well-conserved molecular chaperones that bind and fold a a large proportion of proteins in the cell. Many cancer proteins are inherently unstable and need chaperones to maintain activity. We are interested in the basic question of the role of molecular chaperones in breast and prostate cancer.  We are focused in novel ways to manipulate Hsp70 function by either inhibiting specific “helper” co-chaperone proteins such as Hsp40 or by modulating phosphorylation on Hsp70. By “fine-tuning” Hsp70 function, we hope to identify novel ways to destabilize cancer proteins.

The Truman lab incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics and cell culture technologies.  Keywords: protein-protein interactions, protein folding, CRISPR-CAS9, breast cancer, signal transduction, phosphorylation, Hsp70, Hsp90, cell cycle, DNA damage response, yeast genetics.  

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