Bioinformatics
Research Assistant Professor
33451- NC Research Campus – Kannapolis
704-687-7396
Dr. Aleksandr Smirnov received the Ph.D. in Applied Mathematics from Louisiana State University, Baton Rouge, in 2011. He subsequently did a postdoc in Dr. Xiuxia Du’s lab at the University of North Carolina at Charlotte.
Dr. Aleksandr Smirnov’s research interests are in Metabolomics, with a focus on developing new algorithms and software tools for processing raw untargeted Mass Spectrometry data. He has made contributions to multiple software tools for pre-processing raw MS-data, tracking and prioritization of unknown compounds, and visualization of food/compound/pathway/disease relationships. In 2021, he received the Mark P. Styczynski Early Career Award in Computational Metabolomics.
Publications:
– Smirnov, Aleksandr; Liao, Yunfei; Fahy, Eoin; Subramaniam, Shankar; Du, Xiuxia; ADAP-KDB: A Spectral Knowledgebase for Tracking and Prioritizing Unknown GC–MS Spectra in the NIH’s Metabolomics Data Repository, Analytical Chemistry, 93 (36) 12213-12220, 2021
– Aksenov, Alexander A; Laponogov, Ivan; Zhang, Zheng; Doran, Sophie LF; Belluomo, Ilaria; Veselkov, Dennis; Bittremieux, Wout; Nothias, Louis Felix; Nothias-Esposito, Mélissa; Maloney, Katherine N; et al. Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data, Nature biotechnology, 39 (2) 169-173, 2021
– Pluskal, Tomáš; Korf, Ansgar; Smirnov, Aleksandr; Schmid, Robin; Fallon, Timothy R; Du, Xiuxia; Weng, Jing-Ke; Metabolomics data analysis using MZmine, Processing metabolomics and proteomics data with open software, 232-254, 2020
– Du, Xiuxia; Smirnov, Aleksandr; Pluskal, Tomáš; Jia, Wei; Sumner, Susan; Metabolomics data preprocessing using ADAP and MZmine 2, Computational Methods and Data Analysis for Metabolomics, 25-48, 2020
– Smirnov, Aleksandr; Qiu, Yunping; Jia, Wei; Walker, Douglas I; Jones, Dean P; Du, Xiuxia; ADAP-GC 4.0: application of clustering-assisted multivariate curve resolution to spectral deconvolution of gas chromatography–mass spectrometry metabolomics data, Analytical chemistry, 91 (14) 9069-9077, 2019
– Du, Xiuxia; Smirnov, Aleksandr; Jia, Wei; A preparatory study of how to construct consensus mass spectra of recurrent unknown metabolites from untargeted GC–MS metabolomics data, International Journal of Mass Spectrometry, 427, 73-78, 2018
– Smirnov, Aleksandr; Jia, Wei; Walker, Douglas I; Jones, Dean P; Du, Xiuxia; ADAP-GC 3.2: graphical software tool for efficient spectral deconvolution of gas chromatography–high-resolution mass spectrometry metabolomics data, Journal of proteome research, 17 (1) 470-478, 2018
– Antipov, YA; Smirnov, AV; Fundamental solution and the weight functions of the transient problem on a semi‐infinite crack propagating in a half‐plane, ZAMM‐Journal of Applied Mathematics and Mechanics/Zeitschrift für Angewandte Mathematik und Mechanik, 96 (10) 1156-1174, 2016
– Antipov, YA; Smirnov, AV; Subsonic propagation of a crack parallel to the boundary of a half-plane, Mathematics and Mechanics of Solids, 18 (2) 153-167, 2013
– Sil’vestrov, VV; Smirnov, AV; The Prandtl integrodifferential equation and the contact problem for a piecewise homogeneous plate, Journal of Applied Mathematics and Mechanics, 74 (6) 679-691, 2010
– Antipov, YA; Smirnov, AV; Fundamental solution and the weight functions of the transient problem on a semi‐infinite crack propagating in a half‐plane, ZAMM‐Journal of Applied Mathematics and Mechanics/Zeitschrift für Angewandte Mathematik und Mechanik, 96 (10) 1156-1174, 2016
– Antipov, YA; Smirnov, AV; Subsonic propagation of a crack parallel to the boundary of a half-plane, Mathematics and Mechanics of Solids, 18 (2) 153-167, 2013
– Sil’vestrov, VV; Smirnov, AV; The Prandtl integrodifferential equation and the contact problem for a piecewise homogeneous plate, Journal of Applied Mathematics and Mechanics, 74 (6) 679-691, 2010
