Faculty Connections
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Full-Text Search

Joseph S Marino

Kinesiology
exercise interventions
insulin resistance
skeletal muscles
type 2 diabetes
Related People
Heather T Anderson
Crystal N Piper
MarinoProfile:

The Marino lab works to advance our understanding of the regulation of skeletal muscle mass and metabolism in health and disease.  Our lab utilizes human, rodent, and tissue culture approaches to investigate complex cellular and molecular biological interactions as well whole organism responses. Our current research interests include:

  • The effect of soluble factors from an oncogenic environment on skeletal muscle cell proliferation and myotube formation
  • The efficacy of Metformin as a tumor suppressor
  • The role of microRNAs in the regulation of skeletal muscle insulin responsiveness
  • The effect of sleep disturbance on athletic performance and health
  • Resistance training adaptations in healthy and diseased skeletal muscle

Education:

  • B.A. (2003) Exercise Science, Adelphi University, Garden City, NY
  • M.A. (2004) Exercise Science, Adelphi University, Garden City, NY
  • Ph.D. (2009) Applied Physiology, University of Toledo, Toledo, OH. Area of Study:  The contribution of exercise-induced inflammation to skeletal muscle hypertrophy
  • Postdoctoral Training (2013) University of Toledo, College of Medicine, Center for Diabetes and Endocrine Research, Toledo, OH. Area of Study: Neuro-endocrine regulation of obesity and metabolic disease
Faculty positions:
2013-present:  Associate Professor, University of North Carolina at Charlotte, Charlotte, NC

Peer Reviewed Publications (*Students Under Dr. Marino’s Mentorship):

Joshua R. Huot, Brian Thompson, Charlotte McMullen, Joseph S. Marino, Susan T. Arthur. GSI treatment preserves protein synthesis in C2C12 myotubes. Cells 2021, 10, 1786

*Nicole L. Stott and Joseph S. Marino. High fat rodent models of type 2 diabetes: From rodent to human. Nutrients 2020, 12, 3650

Joshua R. Huot, Joseph S. Marino, Micheal J. Turner, and Susan T. Arthur. Notch Inhibition via GSI Treatment Elevates Protein Synthesis in C2C12 Myotubes. Biology 2020, 2; 9(6):115

Benjamin DH Gordon, Sarah Whitmire, Emily W. Zacherle, Shelton Doyle, Sanjeev Gulati, Larry J. Leamy, Joseph Marino, Jeanette Bennett, Adam Reitzel, Ian Swaine, Reuben Howden. “Get a Grip on Hypertension” Exploring the use of isometric handgrip training in cardiopulmonary rehabilitation. J Cardiopulm Rehabil and preven 2019, 39(6):E31-E34

Benjamin DH Gordon, Erin Vinoski, Jan Warren-Findlow, Joseph Marino, Jeanette Bennett; Adam Reitzel, Larry Leamy, Ian Swaine, Reuben Howden. A comparison of blood pressure reduction following 12-weeks of isometric exercise training either in the laboratory or at home. J Am Soc Hypertens 12(11) (2018) 798-808

*Bailey Peck, Josh Huot, *Tim Renzi, Susan T. Arthur, Michael J. Turner, and Joseph S. Marino. Mice Lacking PKCθ in Skeletal Muscle Have Reduced Intramyocellular Lipid Accumulation and Increased Insulin Responsiveness in Skeletal Muscle. Am J Physiology Regul Integr Comp Physiology. 2018, 1;314(3):R468-R477

Bennett, J. M., Marino, J. S., *Peck, B., Roos, L. G., Joseph, K. M., Carter, L. B., Smith, C. B., Rohleder, N. & Coffman, M. J.  Smokers display reduced glucocorticoid sensitivity prior to symptomatic chronic disease development. Ann Behav Med. 2018, 13;52(10):830-841

Joseph S. Marino, Cynthiya Ruban, Bill Saunders, MPH; Christopher M. Blanchette, The association of COPD exacerbations with new onset type 2 diabetes among Medicare participants. JHEOR 2017;5(2):183-93

*Bailey Peck, *Timoty Renzi, Hannah Peach, Jane Gaultney, and Joseph S. Marino. Examination of Risk for Sleep Disordered Breathing among College Football Players. J Sport Rehabil Epub 2018, Sep29. 2019 1;28(2):126-132

Bennett, J. M., Roos, L. G., Marino, J. S., Rohleder, N., & Coffman, M. J. (2017).  Healthy smokers: An oxymoron? Maybe, but it is more complicated than that. In J. P. Sturmberg (Ed) The Value of Systems and Complexity Sciences for Healthcare – Proceedings of the 2nd International Conference of Systems and Complexity in Health (pp 23-39). New York: Springer.

Joseph S. Marino, Lance A. Stechschulte, David E. Stec, Andrea Nestor-Kalinoski, Sydni Coleman, and Terry D. Hinds, Jr.  Glucocorticoid receptor β induces hepatic steatosis by augmenting inflammation and inhibition of the peroxisome proliferator-activated receptor (PPAR) α. (2016)  J. Biol. Chem. doi: 10.1074/jbc.M116.752311 jbc.M116.752311. *Selected as Paper of the Week, now known as Editors Pick. http://www.jbc.org/content/291/50/25776/suppl/DCAuthor_profile

Terry D. Hinds Jr., *Bailey Peck, *Evan Shek, *Steven Stroup, *Jennifer Hinson, Susan Arthur, and Joseph S Marino. Overexpression of Glucocorticoid Receptor Beta Enhances Myogenesis and Reduces Catabolic Gene Expression. Int. J. Mol. Sci. 2016, 17(2), 232; doi:10.3390/ijms17020232

Turner MJ, Guderian S, Wikstrom EA, Huot JR, *Peck BD, Arthur ST, Marino JS, Hubbard-Turner T. Altered left ventricular performance in aging physically active mice with an ankle sprain injury. Age. 2016 Feb;38(1):15. doi: 10.1007/s11357-016-9877-2.

John K, Marino JS, Sanchez ER, Hinds TD Jr.  The Glucocorticoid Receptor: Cause of Cure for Obesity? Am J Physiol Endocrinol Metab. 2015 Dec 29:ajpendo.00478.2015. doi: 10.1152/ajpendo.00478.2015

Lance A. Stechschutle, Leah Wuescher, Joseph S. Marino, Jennifer W. Hill, Charis Eng, and Terry D. Hinds, Jr. Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN. (2014) J. Biol. Chem. Doi:10.1074/jbc.M113.544072

Abigail R. Dowling, Laura B. Nedorezov, Xiaoliang Qiu, Joseph S. Marino, Jennifer W. Hill. Genetic Factors Modulate the Impact of Pubertal Androgen Excess on Insulin Sensitivity and Fertility. (2013)  PLOS One 8(11): e79849. doi:10.1371/journal.pone.0079849

Joseph S. Marino, Terry D. Hinds, Jr., *Rachael A. Hoover, *Eric Ondrus, *Jeremy L. Onion,  Abigail Dowling, Thomas McLoughlin, Edwin R. Sanchez and Jennifer W. Hill.  Suppression of Protein Kinase C Theta Contributes to Enhanced Myogenesis in vitro via IRS1 and ERK1/2. BMC Cell Biology 2013, 14:39

Christopher L. Dearth, Qingnian Goh, Joseph S. Marino, Peter A. Cicinelli, Maria J. Torres-Palsa, Philippe Pierre, Randall G. Worth, Francis X. Pizza. (2013)  Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. PLOS One 8(3): e58486. doi:10.1371/journal.pone.0058486

Xiaoliang Qiu, Abigail R Dowling, Joseph S Marino, Latrice D Faulkner, Jens C. Brüning, Carol F Elias, Benjamin Bryant, Jennifer W Hill. (2013) Delayed Puberty but Normal Fertility in Mice with Selective Deletion of Insulin Receptors from Kiss1 Cells. 2013. Endocrinology. March 2013, 154(3):1337-1348

Marino JS, Iler J, Dowling AR, Chua S, Bruning JC, et al. (2012) Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence of Adipocyte Hypertrophy and Tissue-Specific Inflammation. PLoS ONE 7(10):e48643.doi:10.1371/journal.pone.0048643

J.S. Marino, S.J. Peterson, M. Li, L. Vanella, K. Sodhi, J. W. Hill, and  N.G. Abraham.  ApoA-1 Mimetic Restores Adiponectin Expression and Insulin Sensitivity Independent of Changes in Body Weight in Female Obese Mice.  Nutr Diabetes. 2012 March 2(3): e33.

P. R. Patel, S. K. Ramakrishnan, M. K. Kaw, C. K. Raphael, S. Ghosh, J. S. Marino, G. Heinrich, S. J. Lee, R. E. Bourey, J. W. Hill, D. Y. Jung, D. A. Morgan, J. K. Kim S. K. Rahmouni, M. Najjar. Increased Metabolic Rate and Insulin Sensitivity in Male Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2. Diabetologia. 2012 Mar;55(3):763-72

Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab. 2011 Jul;22(7):275-85

Marino JS, Tausch BJ, Dearth CL, Manacci MV, McLoughlin TJ, Rakyta SJ, Linsenmayer MP, Pizza FX. β2-Integrins contribute to skeletal muscle hypertrophy in mice. Am J Physiol Cell Phsiol 295: C1026-1036, 2008


FUNDED GRANTS

Mechanism: Target Research Incentive Seed Program

Title: Metformin and Non-Small Cell Lung Cancer: Outcomes Analysis of SEER-Medicare Beneficiaries and Pilot Animal Study

Role: P.I.

Duration: 07/01/18 to 6/30/19. No cost extension to 9/30/19

Amount: $30,099.00

Mechanism: UNC Charlotte Faculty Research Grant

Title: Mechanisms regulating skeletal muscle insulin resistance in the battle against type 2 diabetes.

Role: P.I.

Amount: $6,000

Duration: 07/2014 to 12/2015

Mechanism: Nova Biomedical Corporation

Title: The effect of isometric exercise on the regulation of blood glucose

Role: P.I.

Amount: ~$2500. Support is provided as needed in the form of glucose testing equipment to enhance the research experience for undergraduate and graduate students.

Duration: 2014-2016

Mechanism: UNC Charlotte Faculty Research Grant

Title: Regulation of the insulin signaling pathway by microRNA

Role: P.I.

Amount: $6,000

Duration: 1/1/2017 to 6/30/2018

FUNDED GRADUATE AND UNDERGRADUATE GRANTS

Mechanism: NCAA Graduate Student Research Award

Title: Examination of risk for sleep disordered breathing among college football players

Role: Mentor (P.I. Bailey Peck; Master’s student)

Amount: $7,500

Duration: 12/2014 to 12/2015


Conference Symposiums:

Mike Turner, Joseph S. Marino, and Susan Arthur. Potential coordinated participants in the age-related declines in cardiovascular, metabolic, and skeletal muscle systems. (South East ACSM 2017)

______________________________________________________________________________

Press Releases:

Examination of Risk for Sleep Disordered Breathing among College Football Players

______________________________________________________________________________

Current teaching:
  • Exercise Physiology: Principles and Application (UG)
  • Principles of Strength and Conditioning (UG)
  • Exercise Testing and Prescription (UG)
  • Research Methods in Kinesiology (UG,G)
  • Adv. Principles of Strength and Conditioning (G)

Honors and Awards
  • The office of Disability Services Outstanding Faculty Award, UNC Charlotte (2013-2014)
  • The College of Health and Human Services Faculty Excellence Award in Mentoring, UNC Charlotte (2016)
______________________________________________________________________________
Certifications
Certified Strength and Conditioning Specialist
USA Hockey Coaching Education Program Level 3
______________________________________________________________________________
Community Engagement
National Science Festival, The College of Health and Human Services Representative
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