Abstract
![Abstract Image](https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bcches/2018/bcches.2018.29.issue-9/acs.bioconjchem.8b00518/20180914/images/medium/bc-2018-005185_0011.gif)
N-(3-Iodopropyl)isatoic anhydride (IPIA) has been demonstrated to serve as an efficient substrate for the development of an extended bioconjugation platform. Derivatives of IPIA are water-soluble and adaptable and share a common chromophore, rendering them easily quantifiable. We demonstrate the preparation of the readily diversified bioconjugation platform technology and application of the reagents in RNA-SHAPE analysis.