Faculty Connections
Faculty Connections

About this site

Faculty Connections is an aggregation of UNC Charlotte faculty profiles.

Full-time faculty who want to update their profile information, see:
Connection Update

UNC Charlotte faculty and staff can log in with their NinerNET user accounts.
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Colleges & Departments

  • ►Belk College of Business
    • ►Business Info Systems/Operations
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    • ►Turner School of Accountancy
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    • ►Bioinformatics Research Center
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  • ▼College of Liberal Arts & Sciences
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    • ▼Biological Sciences
      • Aaron Kampe
      • Adam Reitzel
      • Andrew Truman
      • Bao-Hua Song
      • Carrie Wells
      • Christine Richardson
      • Danillo Gardenal Augusto
      • Didier Dreau
      • Elaine Luo
      • Ellen Wisner
      • Eugenia Lo
      • Farzana Ferdous
      • Ian Marriott
      • James Oliver
      • Jennifer Warner
      • Jian Zhang
      • Junya Tomida
      • Kausik Chakrabarti
      • Kenneth Bost
      • Kristen Funk Johnson
      • M. Brittany Johnson
      • Maria Paola Lopez-Duarte
      • Mark Clemens
      • Matthew Parrow
      • Michelle Pass
      • Morgan Carter
      • Pinku Mukherjee
      • Richard Chi
      • Richard Tankersley
      • Ru Zhou
      • Samantha Furr
      • Shan Yan
      • Shankari Somayaji
      • Sharon Bullock
      • Stanley Schneider
      • Tingting Xiang
      • Todd Steck
      • Tonya Bates
      • Tuan Cao
      • Valery Grdzelishvili
      • Yunfeng Lin
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    • ►Writing, Rhetoric, and Digital Studies
    • Jonathan Overton
    • Kailas Venkitasubramanian
    • Ritchie Dudley
    • Umesh Silwal
  • ►Lee College of Engineering
    • ►Civil and Environmental Engr
    • ►Electrical & Computer Engineering
    • ►Engineering Tech & Constr Mgmt
    • ►EPIC
    • ►Mech Engineering & Engineering Sci
    • ►Student Dev & Success
    • ►Systems Engin & Engin Management
  • ►School of Data Science (SDS)

Programs, Centers & Initiatives

  • ►Center for Applied Geographic Information Science
  • ►Metropolitan Studies
    • ►Urban Institute

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Full-Text Search

Andrew Truman

Biological Sciences
breast cancer
cancer biology
cell biology
CRISPR
mass spectrometry
molecular biology
molecular chaperones
phosphorylation
prostate cancer
protein function
protein-protein interactions
proteins
proteomics
signal transduction mechanisms
signaling pathways
yeast
Related People
Shan Yan
Pinku Mukherjee
Didier Dreau
Crystal N Piper
Junya Tomida
Tingting Xiang
Christine Richardson
Brian Cooper
Joanna Krueger
Danillo Gardenal Augusto
Adam Reitzel
Richard Chi
Colleen Eade
Jerry Troutman

The Truman Lab has moved sites! Please see:

Trumanlab.org

For undergraduate, graduate or postdoctoral research opportunities, please see here:

Research Opportunities

Hsp70 and Hsp90 are well-conserved molecular chaperones that bind and fold a a large proportion of proteins in the cell. Many cancer proteins are inherently unstable and need chaperones to maintain activity. We are interested in the basic question of the role of molecular chaperones in breast and prostate cancer.  We are focused in novel ways to manipulate Hsp70 function by either inhibiting specific “helper” co-chaperone proteins such as Hsp40 or by modulating phosphorylation on Hsp70. By “fine-tuning” Hsp70 function, we hope to identify novel ways to destabilize cancer proteins.

The Truman lab incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics and cell culture technologies.  Keywords: protein-protein interactions, protein folding, CRISPR-CAS9, breast cancer, signal transduction, phosphorylation, Hsp70, Hsp90, cell cycle, DNA damage response, yeast genetics.  

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