Faculty Connections
Faculty Connections

About this site

Faculty Connections is an aggregation of UNC Charlotte faculty profiles.

Full-time faculty who want to update their profile information, see:
Connection Update

UNC Charlotte faculty and staff can log in with their NinerNET user accounts.
Log In

Colleges & Departments

  • ►Belk College of Business
    • ►Business Info Systems/Operations
    • ►Economics
    • ►Finance
    • ►Management
    • ►Marketing
    • ►Turner School of Accountancy
  • ►College of Arts + Architecture
    • ►Art & Art History
    • ►Dance
    • ►Music
    • ►Performing Arts Services
    • ►School of Architecture
    • ►Theatre
  • ►College of Computing & Informatics
    • ►Bioinformatics and Genomics
    • ►Bioinformatics Research Center
    • ►Computer Science
    • ►Software & Information Systems
  • ►College of Education
    • ►Counseling
    • ►Ctr For STEM Education
    • ►Educational Leadership
    • ►Middle Grades Secondary & K-12
    • ►Reading & Elementary ED
    • ►School & Community Partnerships
    • ►Special Ed & Child Dev
  • ►College of Health & Human Services
    • ►Appl Phys Hlth & Clin Sci
    • ►Kinesiology
    • ►Public Health Sciences
    • ►School of Nursing
    • ►School of Social Work
  • ▼College of Liberal Arts & Sciences
    • ►Africana Studies
    • ►Anthropology
    • ▼Biological Sciences
      • Aaron Kampe
      • Adam Reitzel
      • Andrew Truman
      • Bao-Hua Song
      • Carrie Wells
      • Christine Richardson
      • Danillo Gardenal Augusto
      • Didier Dreau
      • Elaine Luo
      • Ellen Wisner
      • Eugenia Lo
      • Farzana Ferdous
      • Ian Marriott
      • James Oliver
      • Jennifer Warner
      • Jian Zhang
      • Junya Tomida
      • Kausik Chakrabarti
      • Kenneth Bost
      • Kristen Funk Johnson
      • M. Brittany Johnson
      • Maria Paola Lopez-Duarte
      • Mark Clemens
      • Matthew Parrow
      • Michelle Pass
      • Morgan Carter
      • Pinku Mukherjee
      • Richard Chi
      • Richard Tankersley
      • Ru Zhou
      • Samantha Furr
      • Shan Yan
      • Shankari Somayaji
      • Sharon Bullock
      • Stanley Schneider
      • Tingting Xiang
      • Todd Steck
      • Tonya Bates
      • Tuan Cao
      • Valery Grdzelishvili
      • Yunfeng Lin
    • ►Chemistry
    • ►Communication Studies
    • ►Criminal Justice and Criminology
    • ►English
    • ►Geography and Earth Sciences
    • ►Global Studies
    • ►History
    • ►Languages and Culture Studies
    • ►Mathematics and Statistics
    • ►Philosophy
    • ►Physics and Optical Science
    • ►Political Science and Public Administration
    • ►Psychological Science
    • ►Religious Studies
    • ►Sociology
    • ►Writing, Rhetoric, and Digital Studies
    • Jonathan Overton
    • Kailas Venkitasubramanian
    • Ritchie Dudley
    • Umesh Silwal
  • ►Lee College of Engineering
    • ►Civil and Environmental Engr
    • ►Electrical & Computer Engineering
    • ►Engineering Tech & Constr Mgmt
    • ►EPIC
    • ►Mech Engineering & Engineering Sci
    • ►Student Dev & Success
    • ►Systems Engin & Engin Management
  • ►School of Data Science (SDS)

Programs, Centers & Initiatives

  • ►Center for Applied Geographic Information Science
  • ►Metropolitan Studies
    • ►Urban Institute

Top Links

  • performing arts
  • art
  • visual arts
  • architecture
  • diversity
  • music
  • gender
  • culture
  • theatre
  • race
  • design
  • education
  • arts and community
  • arts education
  • dance
  • environment
  • robotics
  • health disparities
  • art history
  • machine learning
  • sexuality
  • statistics
  • rhetoric
  • composition
  • computer science
  • sustainability
  • health
  • ecology
  • evolution
  • literacy
  • vulnerable populations
  • mental health
  • urban design
  • collaboration
  • politics
  • biostatistics
  • popular culture
  • mathematical physics
  • teacher education
  • music education
  • artificial intelligence
  • ethics
  • social media
  • molecular biology
  • orchestra

Full-Text Search

Shan Yan

Biological Sciences
cancer biology
cell biology
developmental biology
environmental health
molecular biology
xenopus laevis
Related People
Deborah Thomas
Andrew Truman
Richard Chi
Colleen Eade
Danillo Gardenal Augusto
Junya Tomida
Tingting Xiang
Jerry Troutman
Christine Richardson
Didier Dreau
Adam Reitzel

Shan Yan, PhD, Professor

Research Interests: Molecular Mechanisms of Genome Integrity

Research Areas: Cancer Biology, Cell Biology, Molecular Biology, Developmental Biology, Environmental Health, Xenopus laevis

Lab website:

 

All eukaryotes have evolved an elaborate network, DNA damage response (DDR), to detect aberrant DNA structures or stalled replication forks, and to coordinate DNA repair, checkpoint activation, cell cycle arrest, and senescence/apoptosis. From a broader perspective, the DDR machinery plays important roles in fundamental biomedical fields, such as DNA replication, DNA damage repair, cell cycle regulation, transcription, apoptosis, senescence, and autophagy. Defective DDR pathways compromise genomic integrity, leading to human diseases.

The research projects in the Yan lab focus on several essential questions linking DDR and human diseases, such as cancer, sepsis, aging, and neurodegenerative disorders. Using biochemical, molecular and cell biology approaches, our laboratory is interested in crucial issues in maintaining genomic stability, including checkpoint activation, DNA damage repair, and translesion synthesis (TLS) in response to DNA replication stress and oxidative stress as well as other stressful conditions. Ultimately, our research program will help to better understand how cells maintain genome stability and to provide novel clues for detection and treatment of human diseases. Xenopus egg extracts and mammalian cell lines will be used as model systems to investigate fundamental biomedical questions with cutting-edge technologies. One aim of this lab is to establish a motivated and productive research team. You are welcome to visit and/or join us!

 

Research Projects:

(1) DNA Single-strand break repair and signaling

(2) Oxidative stress response and redox regulation

(3) DNA replication stress response in genome stability

(4) DNA repair and DNA damage response pathways in human diseases (cancer, sepsis, aging, and neurodegenerative diseases)

 

 

Representative Publications (*corresponding author):

(1) Lin Y§,#, Raj J§,‡, Li J#, Ha A¶, Hossain MA¶, Richardson C, Mukherjee P, Yan S*. 2020. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research. 48(4):1925-1940 (PMCID: PMC7038996; PMID: 31828326)

 

(2) Lin Y§, Bai L§, Cupello S, Hossain MA, Deem B, McLeod M, Raj J, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157)

 

(3) Wallace BD§, Berman Z§,, Mueller GA, Lin Y, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S*, Williams RS*. 2017.  APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 114 (2):304-309. (PMCID: PMC5240719; PMID: 28028224)

 

(4) Yan S*, Sorrell M, Berman Z¶. 2014. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cellular and Molecular Life Sciences. 71 (20): 3951-3967. (PMCID: PMC4176976; PMID: 24947324)

 

(5)  Willis J§, Patel Y§, Lentz B,  Yan S*. 2013. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 110 (26): 10592-10597. (PMCID: PMC3696815; PMID: 23754435).

 

Click the link for the video (~10 minutes):    JoVE-Video

Willis J#, DeStephanis D#, Patel Y, Gowda V, and Yan S*. 2012. Study of the DNA damage checkpoint using Xenopus egg extracts. Journal of Visualized Experiments. (69): e4449 10.3791/4449. DOI: http://dx.doi.org/10.3791/4449 PMCID: PMC3514051.

 

Department of Biological Sciences website: http://biology.uncc.edu/

  • Alerts
  • Jobs
  • Make a Gift
  • Maps / Directions
  • Accessibility IconAccessibility
Follow UNC Charlotte
Facebook Blogger Twitter Flickr YouTube
The University of North Carolina at Charlotte 9201 University City Blvd., Charlotte, NC 28223-0001 · 704-687-UNCC (8622) © 2014 UNC Charlotte | All Rights Reserved | Terms of Use | Policy Statements | Contact Us
Skip to toolbar
  • Log In