§: equal contribution

: undergraduate student

: graduate student

#: postdoctoral fellow/research associate/research faculty

*: corresponding author

>>>: preprint


Publications after joining UNC Charlotte (total=n)



53. McMahon A, …,  Yan S*. 2024. (in revision)

52. Zhao H#, …,  Yan S*. 2024. (In revision)

51. Yan S*, Gaddameedhi S*, Sobol RW*. 2024. Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson. Environmental and Molecular Mutagenesis., 65 (S1): 4-8. (PMID: 38619433; online ahead of print April 15, 2024)  DOI: https://doi.org/10.1002/em.22595



50. Suptela AJ, Radwan Y, Richardson C, Yan S., Afonin KA, Marriott I*. 2023. cGAS mediates the inflammatory responses of human microglial cells to genotoxic DNA damage. Inflammation.  (online published on December 26, 2023). (PMID: 38148453) DOI: https://doi.org/10.1007/s10753-023-01946-8

49. Driscoll G, Yan S*. 2023. Maintaining chromosome and genome stability by the RPA-RNF20-SNF2H cascade. Proceedings of the National Academy of Sciences of the United States of America. 120 (24): e2306455120. (PMCID: PMC10268305; PMID: 37276422). DOI: https://doi.org/10.1073/pnas.2306455120

48. Lin Y#, Li J#, Zhao H#, McMahon A, McGhee K, Yan S*. 2023. APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response. eLife. 12: e82324. (PMCID: PMC10202453; PMID: 37216274)  DOI: https://doi.org/10.7554/eLife.82324

47. Li J#, Yan S*. 2023. Molecular mechanisms of nucleolar DNA damage checkpoint response. Trends in Cell Biology. 33 (5): 361-364. (Online published on March 16, 2023) (PMCID: PMC10215988; PMID: 36933998) DOI: https://doi.org/10.1016/j.tcb.2023.02.003

Public release 03/16/2023. “Researchers highlight nucleolar DNA damage response in fight against cancer” (Please see the link @ Eurekalert or @ UNC Charlotte )

46. McMahon A, Zhao J, Yan S*. 2023. APE2 catalytic function and synthetic lethality draw attention as a cancer therapy target. NAR Cancer. 5 (1):zcad006. (PMCID: PMC9900424 ; PMID: 36755963) DOI: https://doi.org/10.1093/narcan/zcad006



45. Li J#, Zhao H, McMahon A, Yan S*. 2022. APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus. Nucleic Acids Research. 50(18):10503-10525.  (PMCID: PMC9561277; PMID: 36200829) (online published October 6, 2022). DOI: https://doi.org/10.1093/nar/gkac853

Public release 03/16/2023. “Researchers highlight nucleolar DNA damage response in fight against cancer” (Please see the link @ Eurekalert or @ UNC Charlotte )

44. Yan S*, Zhao J*, Kemp M*, Sobol RW*. 2022. Editorial: mechanistic studies of genome integrity, environmental health, and cancer etiology. Frontiers in Cell and Developmental Biology. 10: 1026326. (PMCID: PMC9554606; PMID: 36247007) DOI: https://doi.org/10.3389/fcell.2022.1026326

>>>43. Li J#, Zhao H#, McMahon A, Yan S*. 2022. APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus. bioRxiv. (preprint online August 22, 2022)  DOI: 

>>>42. Lin Y, Li J#, Zhao H#, McMahon A, Yan S*. 2022. APE1 recruits ATRIP to ssDNA in an RPA-independent manner to promote the ATR DNA damage response. bioRxiv. (preprint online August 12, 2022) DOI: https://doi.org/10.1101/2022.08.12.503732

41. Sadaf H, Hong H, Maqbool M, Emhoff K, Lin J, Yan S, Anwer F, and Zhao J. 2022. Multiple myeloma etiology and treatment. Journal of Translational Genetics and Genomics. 6:63-83. (online ahead of print January 20, 2022)  DOI: https://doi.org/10.20517/jtgg.2021.36

40. Tarannum M, Hossain MA, Holmes B, Yan S, Mukherjee P, Vivero-Escoto JL. 2022. Advanced nanoengineering approach for target-specific, spatiotemporal, and ratiometric delivery of gemcitabine-cisplatin combination for improved therapeutic outcome in pancreatic cancer. Small. 18(2):e2104449. (online ahead of print November 10, 2021). (PMCID: PMC8758547; PMID: 34758094) DOI: https://doi.org/10.1002/smll.202104449



39. Hossain MA, Lin Y#, Driscoll G, Li J#, McMahon A, Matos J, Zhao H#, Tsuchimoto D, Nakabeppu Y, Zhao J, Yan S*. 2021. APE2 is a general regulator of the ATR-Chk1 DNA damage response pathway to maintain genome integrity in pancreatic cancer cells. Frontiers in Cell and Developmental Biology. 9:738502. (PMCID: PMC8593216; PMID: 34796173) DOI: https://doi.org/10.3389/fcell.2021.738502

38. Huff LA, Yan S, and Clemens MG. 2021. Mechanisms of Ataxia Telangiectasia Mutated (ATM) control in the DNA damage response to oxidative stress, epigenetic regulation, and persistent innate immune suppression following sepsis. Antioxidants. 10 (7): 1146. (PMCID: PMC8301080; PMID: 34356379) DOI: https://doi.org/10.3390/antiox10071146

37. Hu Y, Yang C, Amorim T, Maqbool M, Lin J, Li C, Fang C, Xue L, Kwart A, Fang H, Yin M, Janocha AJ, Tsuchimoto D, Nakabeppu Y, Jiang X, Mejia-Garcia A, Anwer F, Khouri J, Qi X, Zheng QY, Yu JS, Yan S, LaFramboise T, Anderson KC, Herlitz LC, Munshi NC, Lin J, Zhao J.. 2021. Cisplatin-mediated upregulation of APE2 binding to MYH9 provokes mitochondrial fragmentation and acute kidney injury. Cancer Research (online ahead of print December 7, 2020). 81 (3): 713-723. (PMCID: PMC7869671; PMID: 33288657) DOI: https://doi.org/10.1158/0008-5472.CAN-20-1010

36. Lin Y#, McMahon A, Driscoll G, Bullock S, Zhao J, and Yan S*. 2021. Function and molecular mechanisms of APE2 in genome and epigenome integrity. Mutation Research-Reviews in Mutation Research (online ahead of print November 16, 2020). 787 (January–June): 108347. (PMCID: PMC8287789; PMID: 34083046) DOI: https://doi.org/10.1016/j.mrrev.2020.108347



35. Ha A, Lin Y#, and Yan S*. 2020. A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage. Journal of Biological Chemistry (online ahead of print August 14, 2020). 295 (41): 14222-14235. (PMCID: PMC7549043; PMID: 32817342) DOI: https://doi.org/10.1074/jbc.RA120.014228

Prakash A and Sharma N: Faculty Opinions Recommendation of [Ha A et al., J Biol Chem 2020 295(41):14222-14235]. In Faculty Opinions, 16 Dec 2020; DOI: http://doi.org/10.3410/f.738528228.793580924

34. Yan S* and Vaziri C*. 2020. An introduction for the special issue on environmental health and genome integrity. Environmental and Molecular Mutagenesis., 61 (7): 660-663. (PMCID: PMC7442621; PMID:32683747; online ahead of print July 19, 2020)  DOI: https://doi.org/10.1002/em.22400

33. Jensen KA, Shi X, Yan S*. 2020. Genomic alterations and abnormal expression of APE2 in multiple cancers. Scientific Reports, 10 (1): 3758. (PMCID: PMC7048847; PMID:32111912)  DOI: https://doi.org/10.1038/s41598-020-60656-5

>>>32. Jensen KA, Shi X, Yan S*. 2020. Genomic alterations and abnormal expression of APE2 in multiple cancers. bioRxiv (preprint online January 24, 2020) DOI: https://doi.org/10.1101/2020.01.17.910646

31. Yan S*., Williams C, and Huet Y. 2020. On the reproducibility of methods or findings. Lab Animal. 49 (29-31): 29. (PMCID: PMC7000164; PMID:31988408) DOI: https://doi.org/10.1038/s41684-019-0461-0

30. Lin Y§,#, Raj J§,, Li J#, Ha A, Hossain MA, Richardson C, Mukherjee P, Yan S*. 2020. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research. 48(4):1925-1940. (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: https://doi.org/10.1093/nar/gkz1175

Maiorano D: F1000Prime Recommendation of [Lin Y et al., Nucleic Acids Res 2019]. In F1000Prime, 03 Jan 2020; DOI: https://doi.org/10.3410/f.737076253.793568982



29. Cupello S, Lin Y#, Yan S*. 2019. Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts. Biochemical Journal. 476(24):3791-3804. (PMCID: PMC6959006; PMID: 31808793) DOI: https://doi.org/10.1042/BCJ20190798

28. Yan S*. 2019. Resolution of a complex crisis at DNA 3′ termini. Nature Structural & Molecular Biology. 26 (5): 335-336. (PMCID: PMC6549488; PMID: 30988507) DOI: https://doi.org/10.1038/s41594-019-0215-0

27.  Lin Y#, Ha Anh, Yan S*. 2019. Methods for studying DNA single-strand break repair and signaling in Xenopus egg extracts. Methods in Molecular Biology: DNA Repair Methods and Protocols.  1999: 161-172. (PMCID: PMC6550457; PMID: 31127575) (Balakrishnan and Stewart eds). DOI: https://doi.org/10.1007/978-1-4939-9500-4_9



26.  Hossain MA, Lin Y#, Yan S*. 2018. SSB end resection in genome stability: mechanism and regulation by APE2. International Journal of Molecular Sciences. 19 (8): 2389.  (PMCID: PMC6122073; PMID:30110897) DOI: https://doi.org/10.3390/ijms19082389

25.  Lin Y§,#, Bai L§,#, Cupello S, Hossain MA, Deem B, McLeod M, Raj J, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https://doi.org/10.1093/nar/gky020

24.  Liu SY§, Li X§, Lin ZM, Su L, Yan S*, Zhao B*, Miao J*. 2018. SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis. Cancer Letters. 416: 11-23. (PMCID: PMC5777349; PMID: 29247827) DOI: 10.1016/j.canlet.2017.12.008

23.  Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X*. 2017. Plk1 phosphorylation of Mre11 antagonizes DNA damage response. Cancer Research. 77(12): 3169-3180. (PMCID: PMC5504882; PMID: 28512243) DOI: 10.1158/0008-5472.CAN-16-2787

22. Wallace BD§, Berman Z§, ¶, Mueller GA, Lin Y#, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S*, Williams RS*. 2017.  APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 114 (2): 304-309. (PMCID: PMC5240719; PMID: 28028224) DOI: 10.1073/pnas.1610011114

Public release by Hathaway, J. 01/06/2017. Study characterizes key molecular tool in DNA repair enzymes. (Please see the link @ Eurekalert or @ UNC Charlotte )

21. Acevedo J, Yan S, Michael WM*2016. Direct binding of RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage. Journal of Biological Chemistry. 291 (25): 13124-13131. (PMCID: PMC4933228; PMID: 27129245) (or @BioRxiv

>>> 20. Acevedo J, Yan S, Michael WM*. 2016. Direct binding of RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage. bioRxiv. (preprint online April 23, 2016) DOI: http://dx.doi.org/10.1101/050013

19. Cupello S, Richardson C, and Yan S*. 2016. Cell-free Xenopus egg extracts for studying DNA damage response pathways. International Journal of Developmental Biology. 60 (7-8-9): 229-236. (PMCID: PMC5071109; PMID: 27160070) DOI: http://dx.doi.org/10.1387/ijdb.160113sy



18. Yan S*. 2015. Teaching and learning in a Xenopus research lab. Lab Animal. 44 (8): 327. (PMCID: PMC4545573; PMID: 26200089) DOI: 10.1038/laban.817

17. DeStephanis D§,, McLeod M§,, Yan S*. 2015. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochemical and Biophysical Research Communications. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: http://dx.doi.org/10.1016/j.bbrc.2015.03.077

16. Richardson C*, Yan S, Vestal CG. 2015.  Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cells. International Journal of Molecular Sciences. 16 (2): 2366-2385. (PMCID: PMC4346841; PMID: 25622253) DOI: http://dx.doi.org/10.3390/ijms16022366

15. Yan S*, Sorrell M, Berman Z. 2014. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cellular and Molecular Life Sciences. 71 (20): 3951-3967. (PMCID: PMC4176976; PMID: 24947324) DOI: http://dx.doi.org/10.1007/s00018-014-1666-4

14. Bai L#, Michael WM, Yan S*. 2014. Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts. Cellular Signalling. 26 (5): 857-867. (PMCID: PMC3951582; PMID: 24440306) DOI: http://dx.doi.org/10.1016/j.cellsig.2014.01.006

13. Willis J§,, Patel Y§,, Lentz BYan S*. 2013. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 110 (26): 10592-10597. (PMCID: PMC3696815; PMID: 23754435).  DOI: http://dx.doi.org/10.1073/pnas.1301445110

Public release by Hathaway, J. 06/14/2013. New Findings Regarding DNA Damage Checkpoint Mechanism in Oxidative Stress. (Please see the link @ UNC Charlotte and @ Eurekalert)

Featured by Per, H. 2013. Biochemistry new response mechanism to oxidative stress. Biofutur. (346):17-17. (Click the link here, In French)

Featured in the UNC-TV Science Week of Review: Reward, June 20, 2013 by Lane, D. (Weblink: http://science.unctv.org/content/week-review-reward)

12. Yan S*, Willis J. 2013. WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling. Biochemical and Biophysical Research Communications. 431 (2): 466-471. (PMCID: PMC3577970; PMID: 23333389). DOI: http://dx.doi.org/10.1016/j.bbrc.2012.12.144

Highlighted on the BBRC website under Article Selections along with an introduction by Dr. Michael Lichten, BBRC Editor with expertise in DNA repair (Weblink).

11. Willis J§,, DeStephanis D§,, Patel Y, Gowda V, Yan S*.2012. Study of the DNA damage checkpoint using Xenopus egg extracts. Journal of Visualized Experiments. (69): e4449. (PMCID: PMC3514051; PMID: 23149695). DOI: http://dx.doi.org/10.3791/4449

Video link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514051/

10. Yan S*, Huet Y. 2011. Managing a pending IBC approval. Communicate with PI. Lab Animal. 40 (10): 295-296. (PMID: 22358201). DOI: 10.1038/laban1011-295b

Featured by the Office of Laboratory Animal Welfare (OLAW) at the National Institutes of Health (NIH). (Please see the link here)



Publications before joining UNC Charlotte (total=9)

9.   Van C, Yan S, Michael WM, Waga S, Cimprich KA*. 2010. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. Journal of Cell Biology. 189 (2): 233-246. (PMCID: PMC2856894; PMID: 20385778)

8.  Yan S, Michael WM*. 2009. TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation. Cell Cycle. 8 (18): 2877-2884. (PMID: 19652550)

7.  Yan S, Michael WM*. 2009. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. Journal of Cell Biology. 184 (6): 793-804.  (PMCID: PMC2699152; PMID: 19289795)

6.  Yan S, Lindsay HD, Michael WM*. 2006. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin-bound Chk1 during checkpoint signaling. Journal of Cell Biology. 173 (2): 181-186. (PMCID: PMC2063809; PMID: 16618813)

5.  Yan S*, Tso J*. 2004. Temperature may influence and regulate NF-YB expression in toad oocyte. Biochemical and Biophysical Research Communications. 313 (3): 802-811. (PMID: 14697263)

4.  Yan S, Kong WH*. Gu Z, Zuo JK. 2003. Preparation and preliminary application of monoclonal antibody against cold shock domain of Y-box binding proteins. Journal of Shandong University (Natural Science Edition). 38 (4): 120-124.

3.  Sun ZG, Kong WH, Yan S, Gu Z, Zuo JK*. 2003. The functions in the progesterone-induced oocyte maturation of toad ubiquitin carboxyl-terminal hydrolase (tUCH) are independent of its UCH activity. Shi Yan Sheng Wu Xue Bao (Acta Biologiae Experimentlis Sinica). 36 (2): 105-112. (PMID: 12858507)

2.  Sun ZG, Kong WH, Zhang YJ, Yan S, Lu JN, Gu Z, Lin F, Tso JK*. 2002. A novel ubiquitin carboxyl terminal hydrolase is involved in toad oocyte maturation. Cell Research. 12 (3-4): 199-206. (PMID: 12296378)

1.  Kong WH, Yan S, Gu Z, and Tso JK*. 2002. Developmental stage-dependence of cyclin B1 protein localization and gene expression in rabbit spermatogenesis. Sheng Li Xue Bao (Acta Physiologica Sinica). 54 (5): 400-404. (PMID: 12399820).


If you are interested in our publications, please feel free to email Dr. Yan (shan.yan@uncc.edu).

You can also find our publications from: http://www.researchgate.net/profile/Shan_Yan/

My Bibliography @NCBI: https://www.ncbi.nlm.nih.gov/myncbi/shan.yan.2/bibliography/public/

ORCID: https://orcid.org/0000-0001-8106-6295



JCB 184-6-2009

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